EU-ToxRisk Final Symposium

DAY 1

 Please note that the video has been divided into chapters to facilitate navigation between presentations.

  •  Welcome words from the EU-ToxRisk project coordinator – Bob van de Water (Leiden University)  PDF VIDEO
  • Opening remarks on the EU-ToxRisk project, an EC Horizon 2020 initiative – Christian Desaintes (EC DG Research & Innovation)  PDF ; VIDEO

Part I : New technologies and approaches for toxicology

  • How has EU-ToxRisk impacted on innovative science research outreach – Thomas Steger Hartmann (Bayer)  PDF ; VIDEO
  • iPSC-derived hepatocyte spheroids for liver disease and toxicity assessment – Catherine Verfaillie (University Leuven)  PDF ; VIDEO
  • Biology-inspired microphysiological systems: the asset of multi-organ co-cultures – Uwe Marx (TissUse)  PDF ; VIDEO
  • Interactions with the Tox21 program – Joshua Harrill (U.S. EPA)  PDF ; VIDEO
  • The case of a high-concern toxicity profile screening – Bob van de Water (Leiden University)  PDF ; VIDEO
  • Application of NAMs to detect multisite metabolism – Paul Jennings (VU University Amsterdam)  PDF
  • Application of an AOP approach in a RAx safety assessment: the case of mitochondrial complex I inhibitors – Marcel Leist (University of Konstanz)  PDF ; VIDEO
  • Which NAM testing scope is good enough for risk identification/characterization? – Sylvia Escher (ITEM Fraunhofer) VIDEO

Part II: Implementation of NAM-based approaches in risk assessment workflows

  • How has EU-ToxRisk impacted on NAM implementation in industry? – Andrew White (Unilever)  PDF ; VIDEO
  • A case study combining read-across and NAM, the example of propyl-paraben in systemic toxicity, from A to Z – Gladys Ouedraogo (L’Oreal) 
  • Commercialization Platform: perspectives from partners – Barry Hardy (Edelweiss Connect)  PDF ; VIDEO
  • Podium discussion: an overview on the impact of the EU-ToxRisk strategy from different perspectives – I. Cotgreave, T. S-Hartmann, M. Sachana, G. Kass, C. Desaintes  VIDEO
DAY 2

 

Please note that the video has been divided into chapters to facilitate navigation between presentations.

Part III: Driving regulatory acceptance of NAMs

  • How will EU-ToxRisk impact on NAM regulatory acceptance? – Matthias Herzler (BfR)  PDF ; VIDEO
  • EU-ToxRisk RAx advisory Document – Hennicke Kamp (BASF)  PDF ; VIDEO
  • Interactions with the OECD IATA Case Study programme  – Magdalini Sachana (OECD)  PDF ; VIDEO
  • EU-ToxRisk and EFSA: A common journey towards NGRA – George Kass (EFSA)  PDF ; VIDEO
  • NGRA of developmental neurotoxicity liabilities of neonicotinoid insecticides – Susanne H. Bennekou (Danish Technical University)  PDF ; VIDEO
  • Interactions with other projects/initiatives: the PARC initiative  – Mirjam Luijten (RIVM)  PDF ; VIDEO
  • European Commission perspective on EU-ToxRisk – Maurice Whelan (JRC)  PDF ; VIDEO
  • Ab initio risk assessment – case studies using the EU-ToxRisk toolbox – Andrew White (Unilever)
Poster session I: the EU-ToxRisk Case Studies

Impact #1: Toxicological testing to better predict human risk  PDF

Martijn Mone/Giorgia Pallocca 

The EU-ToxRisk case study approach  PDF

Sylvia Escher/Susanne H.Bennekou

Prediction of microvesicular liver steatosis – a RAx CS: the regulatory impact  PDF

Sylvia Escher

Prediction of microvesicular liver steatosis – a RAx CS: the applied technology  PDF

Sylvia Escher

RAx CS to predict developmental and reproductive toxicity: the regulatory impact  PDF

Dinant Kroese

RAx CS to predict developmental and reproductive toxicity: the applied technology  PDF

Dinant Kroese

Use of integrated approaches to assess neurotoxicity: the regulatory impact  PDF

Bob van de Water

Use of integrated approaches to assess neurotoxicity: the applied technology  PDF

Bob van de Water

High-concern toxicity profile screening: the regulatory impact  PDF

Bob van de Water

High-concern toxicity profile screening: the applied technology  PDF

Bob van de Water

NGRA approach for insecticides induced-DNT: the regulatory impact  PDF

Susanne H. Bennekou

Approach for insecticides induced-DNT: the applied technology NGRA  PDF

Susanne H. Bennekou

Case Study on multi-organ metabolism: the regulatory impact  PDF

Paul Jennings

Case Study on multi-organ metabolism: the applied technology

Paul Jennings

Poster session II: from test system development to commercialization

Technology

An overview of the EU-ToxRisk technologies and sustainable derived datasets  PDF

Johannes Schimming/Martijn Mone

Computational prediction tools used and developed in the project  PDF

Manuel Pastor

PBPK methods used and established in the project  PDF

Iain Gardner

High throughput transcriptomics methods established in the project  PDF

Bob van de Water

High throughput cell reporter tools used and developed in the project  PDF

Catherine Verfaillie

EU-ToxRisk test methods comparison in CSy  PDF

Marcel Leist

Advanced test methods developed in the EU-ToxRisk project  PDF

Wolfgang Moritz

From in vitro to human. Translational strategies in EU-ToxRisk  PDF

Ian Cotgreave

EU-ToxRisk computational methods based on qAOP  PDF

Frederic Bois

Databasing and data sustainability: the EU-ToxRisk approach for data reuse  PDF

Ugis Sarkans

 

Read-Across Strategy

Impact #2: Improved toxicological knowledge to advance read-across procedures  PDF

Hennicke Kamp/Dinant Kroese/Sylvia Escher

The EU-ToxRisk Read-Across Advisory Document  PDF

Hennicke Kamp/Dinant Kroese/Sylvia Escher

 

Commercialization

Impact #3: Commercial exploitation of developed toxicological tests & services  PDF

Bart van de Burg/Barry Hardy

The EU-ToxRisk Commercialization Partnership  PDF

Barry Hardy

The EU-ToxRisk Syngenta Case Study  PDF

Rabea Graepel/Damiano

Dermal Exposure to Propylparaben: joint RAx case study with Cosmetics Europe  PDF

Gladys Ouedraogo

Poster session : Regulatory Impact

Impact #4: Advancement of international co-operation in toxicology  PDF

Giorgia Pallocca/Martijn Mone 

Communication strategy to harmonize research and regulatory needs  PDF

Giorgia Pallocca/Martijn Mone

The ToxTemp document  PDF

Marcel Leist

EU-ToxRisk’s sustainability plan  PDF  

Bob van de Water

Impact #5: Reduced use of laboratory animals in safety testing  PDF 

Andy White/Tom Cull/Giorgia Pallocca

The EU-ToxRisk dissemination activities…in figures  PDF

Giorgia Pallocca