RISK-HUNT3R https://validator.w3.org/feed/docs/rss2.html Highlights from EUROTOX 2025 and the ASPIS Open Symposium RISK-HUNT3R Stakeholder Symposium & General Assembly Third Workshop on the ‘Roadmap towards phasing out animal testing for chemical safety assessment’ Transcriptomic changes and mitochondrial toxicity in response to acute and repeat dose treatment with brequinar in human liver and kidney in vitro models Chemical and Biological Mechanisms Relevant to the Rescue of MG-132-Treated Neurons by Cysteine Biology-inspired dynamic microphysiological system approaches to revolutionize basic research, healthcare and animal welfare Mapping out strategies to further develop human-relevant, new approach methodology (NAM)-based developmental neurotoxicity (DNT) testing Update on the ASPA-NGRA expert workshop in Berlin ASPA-NGRA Workshop  ASPIS advances the path towards phasing out animal testing Meet RISK-HUNT3R Prediction of adverse drug reactions due to genetic predisposition using deep neural networks Knowledge infrastructure for integrated data management and analysis supporting new approach methods in predictive toxicology and risk assessment PathwayNexus: a tool for interactive metabolic data analysis MolCompass: multi-tool for the navigation in chemical space and visual validation of QSAR/QSPR models Assessment of pulmonary fibrosis using weighted gene co-expression network analysis RISK-HUNT3R at WC13 Rio: advancing human-relevant safety testing 3rd RISK-HUNT3R stakeholder symposium Partners & Collaborations Legacy Home Media Center Inhibition of Neural Crest Cell Migration by Strobilurin Fungicides and Other Mitochondrial Toxicants Animal-free Safety Assessment of Chemicals: Project Cluster for Implementation of Novel Strategies (ASPIS) definition of new approach methodologies The long way from raw data to NAM-based information: Overview on data layers and processing steps Interdependency of estradiol-mediated ERα activation and subsequent PR and GREB1 induction to control cell cycle progression Causal, Predictive or Observational? Different Understandings of Key Event Relationships for Adverse Outcome Pathways and their implications on practice Refining Drug-Induced Cholestasis Prediction: An Explainable Consensus Model Integrating Chemical and Biological Fingerprints Utilizing rat kidney gene co-expression networks to enhance safety assessment biomarker identification and human translation Towards a quantitative adverse outcome pathway for liver carcinogenesis: From proliferation to prediction Identifying human toxicodynamic variability: A systematic evidence map of the current knowledge Mechanism-based drug safety testing using innovative in vitro liver models: from DILI prediction to idiosyncratic DILI liability assessment RISK-HUNT3R at the 12th World Congress on Alternatives and Animal Use in the Life Sciences RISK-HUNT3R Best Poster Award at QSAR2023 Mini Symposium – Orienteering for regulatory needs, 14 March 2022 PHD POSITION OPEN IN CELLULAR METABOLOMICS IN TOXICOLOGY The RISK-HUNT3R consortium met in Egmond aan Zee, Netherlands Training: Building next-generation risk assessment (NGRA) case studies using the Alternative Safety Profiling Algorithm (ASPA) RISK-HUNT3R dissemination activities 2025 Genomic and proteomic biomarker landscape in clinical trials Gap Junctional Communication Required for the Establishment of Long-Term Robust Ca2+ Oscillations Across Human Neuronal Spheroids and Extended 2D Cultures Differential Responses of Human iPSC-Derived Microglia to Stimulation with Diverse Inflammogens Cell type heterogeneity in gene co-expression networks: implications for toxicological research An Alternative Safety Profiling Algorithm (ASPA) to transform next generation risk assessment into a structured and transparent process Cell morphology and gene expression: tracking changes and complementarity across time and cell lines Nutrient environment improves drug metabolic activity in human iPSC-derived hepatocytes and HepG2 Testing Strategies for Metabolite-Mediated Neurotoxicity Computational Prediction of Mutagenicity Through Comprehensive Cell Painting Analysis First ASPA Publication ASPA