Non-canonical BIM-regulated energy metabolism determines drug-induced liver necrosis

Cell Death & Differentiation
2024
Lambrecht Rebekka, Rudolf Franziska, Ückert Anna-Katharina, Sladky Valentina C., Phan Truong San, Jansen Jasmin, Naim Samara, Kaufmann Thomas, Keogh Adrian, Kirschnek Susanne, Mangerich Aswin, Stengel Florian, Leist Marcel, Villunger Andreas, Brunner Thomas
DOI: 10.1038/s41418-023-01245-7
PMID: 38001256
Keyword: Acetaminophen* / toxicity · Adenosine Triphosphate / metabolism · Bcl-2-Like Protein 11 / genetics · Bcl-2-Like Protein 11 / metabolism · Chemical and Drug Induced Liver Injury · Energy Metabolism · Hepatocytes / metabolism · Humans · Liver / metabolism · Mitochondria, Liver / metabolism · Necrosis / metabolism · Oxidative Stress