Journal publications
Other output
Journal publications
Links to articles published by consortium members will be available here.
Author
All authors
Ball Nicholas
Blum Jonathan
Botham Philip A
Brüll Markus
Butera Alessio
Béquignon Olivier J.M.
Callegaro Giulia
Capinha Liliana
Carecho Rafael
Cerisier Natacha
Cherianidou Anna
Cronin Mark T D
Dafniet Bryan
Delp Johannes
Dolde Xenia
Drake Christina
Eberhard Philipp
Grebenyuk Sergei
Hardy Barry
Holzer Anna-Katharina
Kunnen Steven J.
Leist Marcel
Meijer Tamara
Ortega-Vallbona Rita
Sosnin Sergey
Yang Huan
van der Stel Wanda
Year
All years
2022
2023
2024
2025
Journal
All Journal
Molecular nutrition & Food Research
Archives of Toxicology
Altex
Antioxidants
Biomolecules
Cell Death & Differentiation
Cell Reports
Cells
Chemical Research in Toxicology
Chemosphere
Computational and structural biotechnology journal
Frontiers in Genetics
Frontiers in Molecular Biosciences
Frontiers in Pharmacology
International Journal of Molecular Sciences
Journal of Chemical Information and Modeling
Journal of Neurochemistry
Liver International
Nature Communications
Regulatory Toxicology and Pharmacology
Science Direct
Stem Cells
Toxicological Sciences
Toxicology Letters
Frontiers in Toxicology
Redox Biology
Bioinformatics
Journal of Cheminformatics
Molecular Informatics
Toxicology in Vitro
Sort By Year
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Biology-inspired dynamic microphysiological system approaches to revolutionize basic research, healthcare and animal welfare
2025 | ALTEX
Marx UweSonja Beken, Zaozao Chen, Eva-Maria Dehne, Ann Doherty, Lorna Ewart, Suzanne C. Fitzpatrick, et al.DOI:https://doi.org/10.14573/altex.2410112 RISK-HUNT3R
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Mapping out strategies to further develop human-relevant, new approach methodology (NAM)-based developmental neurotoxicity (DNT) testing
2025 | ALTEX
Leist MarcelCöllen, Eike, Kristina Bartmann, Jonathan Blum, Kelly Carstens, Ivana Celardo, Nivedita Chatterjee, Marco Corvaro, et al.DOI:https://doi.org/10.14573/altex.2501091 RISK-HUNT3R
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Chemical and Biological Mechanisms Relevant to the Rescue of MG-132-Treated Neurons by Cysteine
2025 | Antioxidants
Ückert Anna-KatharinaIlinca Suciu, Anja Land, Anna-Sophie Spreng, Hannah Welte, Doreen Herzog, Michael Basler, and Marcel LeistDOI:https://doi.org/10.3390/antiox14020128 RISK-HUNT3R
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Transcriptomic changes and mitochondrial toxicity in response to acute and repeat dose treatment with brequinar in human liver and kidney in vitro models
2025 | Toxicology in Vitro
Meijer TamaraBas ter Braak, Liesanne Loonstra-Wolters, Steven J. Kunnen, Barira Islam, Ilinca Suciu, Iain Gardner, Oliver Hatley, Richard Currie, Barry Hardy, Marcel Leist, Bob van de Water, Paul Jennings, Anja WilmesDOI:https://doi.org/10.1016/j.tiv.2025.106010 RISK-HUNT3R
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Animal-free Safety Assessment of Chemicals: Project Cluster for Implementation of Novel Strategies (ASPIS) definition of new approach methodologies
2025 | Environmental Toxicology and Chemistry
Colbourne John KJohn K Colbourne, Sylvia E Escher, Robert Lee, Mathieu Vinken, Bob van de Water, Jonathan H FreedmanDOI:https://doi.org/10.1093/etojnl/vgae093 RISK-HUNT3R
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The long way from raw data to NAM-based information: Overview on data layers and processing steps
2025 | ALTEX
Blum JonathanMarkus Brüll, Jan G. Hengstler, Daniel R. Dietrich, Andreas J. Gruber, Michele Dipalo, Udo Kraushaar, et al.DOI:https://doi.org/10.14573/altex.2412171 RISK-HUNT3R
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Causal, Predictive or Observational? Different Understandings of Key Event Relationships for Adverse Outcome Pathways and their implications on practice
2025 | Environmental Toxicology and Pharmacology
Zhou ZengJeroen L.A. Pennings, Ullrika SahlinDOI:https://doi.org/10.1016/j.etap.2024.104597 RISK-HUNT3R
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The integrated stress response-related expression of CHOP due to mitochondrial toxicity is a warning sign for DILI liability
2024 | Liver International
Vlasveld MatthijsVlasveld Matthijs, Callegaro Giulia, Fisher Ciarán, Eakins Julie, Walker Paul, Lok Samantha, van Oost Siddh, de Jong Brechtje, Pellegrino-Coppola Damiano, Burger Gerhard, Wink Steven, van de Water BobDOI:10.1111/liv.15822 RISK-HUNT3R
PMID: 38217387 -
Non-canonical BIM-regulated energy metabolism determines drug-induced liver necrosis
2024 | Cell Death & Differentiation
Lambrecht RebekkaLambrecht Rebekka, Rudolf Franziska, Ückert Anna-Katharina, Sladky Valentina C., Phan Truong San, Jansen Jasmin, Naim Samara, Kaufmann Thomas, Keogh Adrian, Kirschnek Susanne, Mangerich Aswin, Stengel Florian, Leist Marcel, Villunger Andreas, Brunner ThomasDOI:10.1038/s41418-023-01245-7 RISK-HUNT3R
PMID: 38001256 -
Recommendations on fit-for-purpose criteria to establish quality management for microphysiological systems and for monitoring their reproducibility
2024 | Stem Cell Reports
Pamies DavidPamies David, Ekert Jason, Zurich Marie-Gabrielle, Frey Olivier, Werner Sophie, Piergiovanni Monica, Freedman Benjamin S., Keong Teo Adrian Kee, Erfurth Hendrik, Reyes Darwin R., Loskill Peter, Candarlioglu Pelin, Suter-Dick Laura, Wang Shan, Hartung Thomas, Coecke Sandra, Stacey Glyn, Atac Wagegg Beren, Dehne Eva-Maria, Pistollato Francesca, Leist MarcelDOI:10.1016/j.stemcr.2024.03.009 RISK-HUNT3R
PMID: 38670111 -
Controversy on health-based guidance values for bisphenol A—the need of criteria for studies that serve as a basis for risk assessment
2024 | Archives of Toxicology
Leist MarcelMarcel Leist, Andrea Buettner, Patrick Diel, Gerhard Eisenbrand, Bernd Epe, Petra Först, Tilman Grune, Dirk Haller, Volker Heinz, Michael Hellwig, Hans-Ulrich Humpf, Henry Jäger, Sabine E. Kulling, Angela Mally, Doris Marko, Ute Nöthlings, Elke Röhrdanz, Joachim Spranger, Stefan Vieths, Wim Wätjen, Jan G. HengstlerDOI:10.1007/s00204-024-03778-3 RISK-HUNT3R
PMID: 38806718 -
Mapping Interindividual Variability of Toxicodynamics Using High-Throughput Transcriptomics and Primary Human Hepatocytes from Fifty Donors
2024 | Environmental Health Perspectives
Niemeijer MarijeMarije Niemeijer, Witold Wie Rcek, Shuai Fu, Suzanna Huppelschoten, Peter Bouwman, Audrey Baze, Céline Parmentier, Lysiane Richert, Richard S. Paules, Frederic Y. Bois, Bob van de WaterDOI:10.1289/EHP11891 RISK-HUNT3R
PMID: 38498338 -
Trust your gut: Establishing confidence in gastrointestinal models - An overview of the state of the science and contexts of use
2024 | ALTEX
Debad SusanSusan Debad, David Allen, Omari Bandele, Colin Bishop, Michaela Blaylock, Paul Brown, Maureen K. Bunger, Julia Y. Co, Lynn Crosby, Amber B. Daniel, Steve S. Ferguson, Kevin Ford, Gonçalo Gamboa da Costa, Kristin H. Gilchrist, Matthew W. Grogg, Maureen Gwinn, Thomas Hartung , Simon P. Hogan, Ye Eun Jeong, George E. N. Kass, Elaina Kenyon, Nicole C. Kleinstreuer, Ville Kujala, Patrik Lundquist, Joanna Matheson, Shaun D. McCullough, Angela Melton-Celsa, Steven Musser, Ilung Oh, Oluwakemi B. Oyetade, Sarita U. Patil, Elijah J. Petersen, Nakissa Sadrieh, Christie M. Sayes, Benjamin S. Scruggs, Yu-Mei Tan, Bill Thelin, M. Tyler Nelson, José V. Tarazona, John F. Wambaugh, Jun-young Yang, Changwoo Yu, Suzanne FitzpatrickDOI:10.14573/altex.2403261 RISK-HUNT3R
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Bioactivity Descriptors for in Vivo Toxicity Prediction: Now and the Future
2024 | Expert Opinion on Drug Metabolism & Toxicology
Helmke PallePalle Helmke, Barbara Füzi, Gerhard F EckerDOI:10.1080/17425255.2024.2334308 RISK-HUNT3R
PMID: 38530269 -
Prediction of adverse drug reactions due to genetic predisposition using deep neural networks
2024 | Molecular Informatics
Dafniet BryanDafniet B, Taboureau O.DOI:10.1002/minf.202400021 RISK-HUNT3R
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Qualitative and quantitative concentration-response modelling of gene co-expression networks to unlock hepatotoxic mechanisms for next generation chemical safety assessment
2024 | ALTEX
Kunnen Steven J.Kunnen, S. J., Arnesdotter, E., Willenbockel, C. T., Vinken, M., & van de Water, B.DOI:10.14573/altex.2309201 RISK-HUNT3R
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Characterization of Organic Anion and Cation Transport in Three Human Renal Proximal Tubular Epithelial Models
2024 | Cells
Meijer TamaraMeijer, T., da Costa Pereira, D., Klatt, O. C., Buitenhuis, J., Jennings, P., & Wilmes, A.DOI:10.3390/cells13121008 RISK-HUNT3R
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Preparation of Viable Human Neurites for Neurobiological and Neurodegeneration Studies
2024 | Cells
Brüll MarkusBrüll M, Geese N, Celardo I, Laumann M, Leist M.DOI:10.3390/cells13030242 RISK-HUNT3R
PMID: 38334634 -
Modeling ferroptosis in human dopaminergic neurons: Pitfalls and opportunities for neurodegeneration research
2024 | Redox Biology
Renner NadineNadine Renner, Franziska Schöb, Regina Pape, Ilinca Suciu, Anna-Sophie Spreng, Anna-Katharina Ückert, Eike Cöllen, Federica Bovio, Bruno Chilian, Johannes Bauer, Stefan Röpcke, Jörg Bergemann, Marcel Leist, Stefan SchildknechtDOI:10.1016/j.redox.2024.103165 RISK-HUNT3R
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Knowledge infrastructure for integrated data management and analysis supporting new approach methods in predictive toxicology and risk assessment
2024 | Toxicology in Vitro
Hardy BarryBarry Hardy, Tomaz Mohoric, Thomas Exner, Joh Dokler, Maja Brajnik, Daniel Bachler, Ody Mbegbu, Nora Kleisli, Lucian Farcal, Krzysztof Maciejczuk, Haris Rašidagić, Ghada Tagorti, Pascal Ankli, Daniel Burgwinkel, Divanshu Anand, Ugis Sarkans, Awais AtharDOI:10.1016/j.tiv.2024.105903 RISK-HUNT3R
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PathwayNexus: a tool for interactive metabolic data analysis
2024 | Bioinformatics
Eberhard PhilippPhilipp Eberhard, Martin Kern, Michael Aichem, Hanna Borlinghaus, Karsten Klein, Johannes Delp, Ilinca Suciu, Benjamin Moser, Daniel Dietrich, Marcel Leist, Falk SchreiberDOI:10.1093/bioinformatics/btae310 RISK-HUNT3R
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MolCompass: multi-tool for the navigation in chemical space and visual validation of QSAR/QSPR models
2024 | Journal of Cheminformatics
Sosnin SergeySosnin, S.DOI:10.1186/s13321-024-00888-z RISK-HUNT3R
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Computational Strategies for Assessing Adverse Outcome Pathways: Hepatic Steatosis as a Case Study
2024 | International Journal of Molecular Sciences
Ortega-Vallbona RitaOrtega-Vallbona, R.; Palomino-Schätzlein, M.; Tolosa, L.; Benfenati, E.; Ecker, G.F.; Gozalbes, R.; Serrano-Candelas, E.DOI:10.3390/ijms252011154 RISK-HUNT3R
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Assessment of pulmonary fibrosis using weighted gene co-expression network analysis
2024 | Frontiers in Toxicology
Drake ChristinaDrake Christina , Zobl Walter , Escher Sylvia E.DOI:https://doi.org/10.3389/ftox.2024.1465704 RISK-HUNT3R
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Inhibition of Neural Crest Cell Migration by Strobilurin Fungicides and Other Mitochondrial Toxicants
2024 | Cells
Magel ViktoriaMagel, Viktoria, Jonathan Blum, Xenia Dolde, Heidrun Leisner, Karin Grillberger, Hiba Khalidi, Iain Gardner, Gerhard F. Ecker, Giorgia Pallocca, Nadine Dreser, and et al.DOI:https://doi.org/10.3390/cells13242057 RISK-HUNT3R
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Interdependency of estradiol-mediated ERα activation and subsequent PR and GREB1 induction to control cell cycle progression
2024 | Heliyon
Heldring Muriel M.B. Duijndam, A. Kyriakidou, O.M. van der Meer, M. Tedeschi, J.W. van der Laan, B. van de Water, J.B. BeltmanDOI:https://doi.org/10.1016/j.heliyon.2024.e38406 RISK-HUNT3R
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An Adverse Outcome Pathway Network for Chemically Induced Oxidative Stress Leading to (Non)genotoxic Carcinogenesis
2023 | Chemical Research in Toxicology
Veltman Christina H. J.Veltman Christina H. J., Pennings Jeroen L. A., van de Water Bob, Luijten MirjamDOI:10.1021/acs.chemrestox.2c00396 RISK-HUNT3R
PMID: 37156502 -
Dynamic Metabolic and Transcriptional Responses of Proteasome-Inhibited Neurons
2023 | Antioxidants
Suciu IlincaSuciu Ilinca, Delp Johannes, Gutbier Simon, Ückert Anna-Katharina, Spreng Anna-Sophie, Eberhard Philipp, Karreman Christiaan, Schreiber Falk, Madjar Katrin, Rahnenführer Jörg, Celardo Ivana, Amelio Ivano, Leist MarcelDOI:10.3390/antiox12010164 RISK-HUNT3R
PMID: 36671027 -
Large-scale perfused tissues via synthetic 3D soft microfluidics
2023 | Nat Commun
Grebenyuk SergeiGrebenyuk Sergei, Abdel Fattah Abdel Rahman, Kumar Manoj, Toprakhisar Burak, Rustandi Gregorius, Vananroye Anja, Salmon Idris, Verfaillie Catherine M, Grillo Mark, Ranga AdrianDOI:10.1038/s41467-022-35619-1 RISK-HUNT3R
PMID: 36635264 -
Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models
2023 | Archives of Toxicology
Capinha LilianaCapinha Liliana, Zhang Yaran, Holzer Anna-Katharina, Ückert Anna-Katharina, Zana Melinda, Carta Giada, Murphy Cormac, Baldovini Jenna, Mazidi Zahra, Grillari Johannes, Dinnyés András, van de Water Bob, Leist Marcel, Commandeur Jan N. M., Jennings PaulDOI:10.1007/s00204-022-03436-6 RISK-HUNT3R
PMID: 36576512 -
Identifying multi-scale translational safety biomarkers using a network-based systems approach
2023 | iScience
Callegaro GiuliaCallegaro Giulia, Schimming Johannes P, Piñero González Janet, Kunnen Steven J., Wijaya Lukas S., Trairatphisan Panuwat, van den Berk Linda, Beetsma Kim, Furlong Laura I., Sutherland Jeffrey J., Mollon Jennifer, Stevens James L., van de Water BobDOI:10.1016/j.isci.2023.106094 RISK-HUNT3R
PMID: 36895646 -
Linking chemicals, genes and morphological perturbations to diseases
2023 | Science Direct
Cerisier NatachaCerisier Natacha, Dafniet Bryan, Badel Anne, Taboureau OlivierDOI:10.1016/j.taap.2023.116407 RISK-HUNT3R
PMID: 36736439 -
A continuous in silico learning strategy to identify safety liabilities in compounds used in the leather and textile industry
2023 | Archives of Toxicology
March-Vila EricMarch-Vila Eric, Ferretti Giacomo, Terricabras Emma, Ardao Inés, Brea José Manuel, Varela María José, Arana Álvaro, Rubiolo Juan Andrés, Sanz Ferran, Loza María Isabel, Sánchez Laura, Alonso Héctor, Pastor ManuelDOI:10.1007/s00204-023-03459-7 RISK-HUNT3R
PMID: 36781432 -
Genomic and proteomic biomarker landscape in clinical trials
2023 | Computational and structural biotechnology journal
Piñero JanetPiñero Janet, Rodriguez Fraga Pablo S., Valls-Margarit Jordi, Ronzano Francesco, Accuosto Pablo, Lambea Jane Ricard, Sanz Ferran, Furlong Laura I.DOI:10.1016/j.csbj.2023.03.014 RISK-HUNT3R
PMID: 36968019 -
Making in silico predictive models for toxicology FAIR
2023 | Regulatory Toxicology and Pharmacology
Cronin Mark T DCronin Mark T D, Belfield Samuel J., Briggs Katharine A., Enoch Steven J., Firman James W., Frericks Markus, Garrard Clare, Maccallum Peter H., Madden Judith C., Pastor Manuel, Sanz Ferran, Soininen Inari, Sousoni DespoinaDOI:10.1016/j.yrtph.2023.105385 RISK-HUNT3R
PMID: 37037390 -
G × E interactions as a basis for toxicological uncertainty
2023 | Archives of Toxicology
Suciu IlincaSuciu Ilinca, Pamies David, Peruzzo Roberta, Wirtz Petra H., Smirnova Lena, Pallocca Giorgia, Hauck Christof, Cronin Mark T D, Hengstler Jan G., Brunner Thomas, Hartung Thomas, Amelio Ivano, Leist MarcelDOI:10.1007/s00204-023-03500-9 RISK-HUNT3R
PMID: 37258688 -
REACH out-numbered! The future of REACH and animal numbers
2023 | ALTEX
Rovida CostanzaRovida Costanza, Busquet Francois, Leist Marcel, Hartung ThomasDOI:10.14573/altex.2307121 RISK-HUNT3R
PMID: 37470349 -
Deconvoluting gene and environment interactions to develop an "epigenetic score meter" of disease
2023 | EMBO Molecular Medicine
Butera AlessioButera Alessio, Smirnova Lena, Ferrando-May Elisa, Hartung Thomas, Brunner Thomas, Leist Marcel, Amelio IvanoDOI:10.15252/emmm.202318208 RISK-HUNT3R
PMID: 37538003 -
4.2 million and counting… The animal toll for REACH systemic toxicity studies
2023 | ALTEX
Knight JeanKnight Jean, Hartung Thomas, Rovida CostanzaDOI:10.14573/altex.2303201 RISK-HUNT3R
PMID: 37470350 -
Assessment of Drug-Induced Liver Injury through Cell Morphology and Gene Expression Analysis
2023 | Chemical Research in Toxicology
Lejal VanilleLejal Vanille, Cerisier Natacha, Rouquié David, Taboureau OlivierDOI:10.1021/acs.chemrestox.2c00381 RISK-HUNT3R
PMID: 37652439 -
Collaborative SAR Modeling and Prospective In Vitro Validation of Oxidative Stress Activation in Human HepG2 Cells
2023 | Journal of Chemical Information and Modeling
Béquignon Olivier J.M.Béquignon Olivier J.M., Gómez-Tamayo José C., Lenselink Eelke B., Wink Steven, Hiemstra Steven, Lam Chi Chung, Gadaleta Domenico, Roncaglioni Alessandra, Norinder Ulf, van de Water Bob, Pastor Manuel, van Westen Gerard J.P.DOI:10.1021/acs.jcim.3c00220 RISK-HUNT3R
PMID: 37616385 -
Integrating Mechanistic and Toxicokinetic Information in Predictive Models of Cholestasis
2023 | Journal of Chemical Information and Modeling
Rodríguez-Belenguer PabloRodríguez-Belenguer Pablo, Mangas-Sanjuan Victor, Soria-Olivas Emilio, Pastor ManuelDOI:10.1021/acs.jcim.3c00945 RISK-HUNT3R
PMID: 37660324 -
Assessing network-based methods in the context of system toxicology
2023 | Frontiers in Pharmacology
Valls-Margarit JordiValls-Margarit Jordi, Piñero Janet, Füzi Barbara, Cerisier Natacha, Taboureau Olivier, Furlong Laura I.DOI:10.3389/fphar.2023.1225697 RISK-HUNT3R
PMID: 37502213 -
Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration
2023 | Environment International
Ückert Anna-KatharinaÜckert Anna-Katharina, Rütschlin Sina, Gutbier Simon, Wörz Nathalie Christine, Miah Mahfuzur R., Martins Airton C., Hauer Isa, Holzer Anna-Katharina, Meyburg Birthe, Mix Ann-Kathrin, Hauck Christof, Aschner Michael, Böttcher Thomas, Leist MarcelDOI:10.1016/j.envint.2023.108229 RISK-HUNT3R
PMID: 37797477 -
Analysis of health concerns not addressed by REACH for low tonnage chemicals and opportunities for new approach methodology
2023 | Archives of Toxicology
Botham Philip ABotham Philip A, Cronin Mark T D, Currie Richard, Doe John E, Funk-Weyer Dorothee, Gant Timothy W., Leist Marcel, Marty Sue, van Ravenzwaay Bennard, Westmoreland CarlDOI:10.1007/s00204-023-03601-5 RISK-HUNT3R
PMID: 37755502 -
Usage of model combination in computational toxicology
2023 | Toxicology Letters
Rodríguez-Belenguer PabloRodríguez-Belenguer Pablo, March-Vila Eric, Pastor Manuel, Mangas-Sanjuan Victor, Soria-Olivas EmilioDOI:10.1016/j.toxlet.2023.10.013 RISK-HUNT3R
PMID: 37890682 -
Acceptance criteria for new approach methods in toxicology and human health-relevant life science research – part I
2023 | ALTEX
Holzer Anna-KatharinaHolzer Anna-Katharina, Dreser Nadine, Pallocca Giorgia, Mangerich Aswin, Stacey Glyn, Dipalo Michele, van de Water Bob, Rovida Costanza, Wirtz Petra H., Van Vugt Barbara, Panzarella Giulia, Hartung Thomas, Terron Andrea, Mangas Iris, Herzler Matthias, Marx-Stoeling Philip, Coecke Sandra, Leist MarcelDOI:10.14573/altex.2310021 RISK-HUNT3R
PMID: 37889190 -
Protectiveness of NAM-based hazard assessment - which testing scope is required?
2023 | ALTEX
Zobl WalterZobl Walter, Bitsch Annette, Blum Jonathan, Boei Jan J. W. A., Capinha Liliana, Carta Giada, Castell José, Davoli Enrico, Drake Christina, Fisher Ciarán, Heldring Muriel M., Islam Barira, Jennings Paul, Leist Marcel, Pellegrino-Coppola Damiano, Schimming Johannes P, Snijders Kirsten E., Tolosa Laia, van de Water Bob, van Vugt-Lussenburg Barbara M. A., Walker Paul, Wehr Matthias M., Wijaya Lukas S., Escher Sylvia E.DOI:10.14573/altex.2309081 RISK-HUNT3R
PMID: 38048429 -
Definition of the Neurotoxicity-Associated Metabolic Signature Triggered by Berberine and Other Respiratory Chain Inhibitors
2023 | Antioxidants
Suciu IlincaSuciu Ilinca, Delp Johannes, Gutbier Simon, Suess Julian, Henschke Lars, Celardo Ivana, Mayer Thomas U., Amelio Ivano, Leist MarcelDOI:10.3390/antiox13010049 RISK-HUNT3R
PMID: 38247474 -
Circulating (Poly)phenol Metabolites: Neuroprotection in a 3D Cell Model of Parkinson’s Disease
2022 | Molecular nutrition & Food Research
Carecho RafaelCarecho Rafael, Figueira Inês, Terrasso Ana Paul, Godinho-Pereira Joana, de Oliveira Sequeira Catarina, Azeredo Pereira Sofia, Milenkovic Dragan, Leist Marcel, Brito Catarina, Nunes Dos Santos CláudiaDOI:10.1002/mnfr.202100959 RISK-HUNT3R
PMID: 34964254 -
A framework for chemical safety assessment incorporating new approach methodologies within REACH
2022 | Archives of Toxicology
Ball NicholasBall Nicholas, Bars Remi, Botham Philip A, Cuciureanu Andreea, Cronin Mark T D, Doe John E, Dudzina Tatsiana, Gant Timothy W., Leist Marcel, van Ravenzwaay BennardDOI:10.1007/s00204-021-03215-9 RISK-HUNT3R
PMID: 35103819 -
Next-generation risk assessment of chemicals – Rolling out a human-centric testing strategy to drive 3R implementation: The RISK-HUNT3R project perspective
2022 | Altex
Pallocca GiorgiaPallocca Giorgia, Moné Martijn J., Kamp Hennicke, Luijten Mirjam, van de Water Bob, Leist MarcelDOI:10.14573/altex.2204051 RISK-HUNT3R
PMID: 35404467 -
Specific Attenuation of Purinergic Signaling during Bortezomib-Induced Peripheral Neuropathy In Vitro
2022 | International Journal of Molecular Sciences
Holzer Anna-KatharinaHolzer Anna-Katharina, Suciu Ilinca, Karreman Christiaan, Goj Thomas, Leist MarcelDOI:10.3390/ijms23073734 RISK-HUNT3R
PMID: 35409095 -
Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation
2022 | Archives of Toxicology
van der Stel Wandavan der Stel Wanda, Yang Huan, Vrijenhoek Nanette G., Schimming Johannes P., Callegaro Giulia, Carta Giada, Darici Salihanur, Delp Johannes, Forsby Anna, White Andrew, le Dévédec Sylvia, Leist Marcel, Jennings Paul, Beltman Joost B, van de Water Bob, Danen ErikDOI:10.1007/s00204-021-03160-7 RISK-HUNT3R
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Classification of Developmental Toxicants in a Human iPSC Transcriptomics-Based Test
2022 | Chemical Research in Toxicology
Cherianidou AnnaCherianidou Anna, Seidel Florian, Kappenberg Franziska, Dreser Nadine, Blum Jonathan, Blüthgen Nils, Edlund Karolina, Henry Margit, Leist Marcel, Madjar Katrin, Marchan Rosemarie, Meisig Johannes, Rahnenführer Jörg, Rotshteyn Tamara, Sachinidis Agapios, Waldmann Tanja, Hengstler Jan G.DOI:10.1021/acs.chemrestox.1c00392 RISK-HUNT3R
PMID: 35416653 -
Distinct and Dynamic Transcriptome Adaptations of iPSC-Generated Astrocytes after Cytokine Stimulation
2022 | Cells
Spreng Anna-SophieSpreng Anna-Sophie, Brüll Markus, Leisner Heidrun, Suciu Ilinca, Leist MarcelDOI:10.3390/cells11172644 RISK-HUNT3R
PMID: 36078052 -
Generation of Human Nociceptor-Enriched Sensory Neurons for the Study of Pain-Related Dysfunctions
2022 | Stem Cells
Holzer Anna-KatharinaHolzer Anna-Katharina, Karreman Christiaan, Furmanowsky Lara-Seline, Wohlfarth Harald, Loser Dominik, Dirks Wilhelm G., González Emilio Pardo, Leist MarcelDOI:10.1093/stcltm/szac031 RISK-HUNT3R
PMID: 35689659 -
On the Usefulness of Animals as a Model System (Part II): Considering Benefits within Distinct Use Domains
2022 | ALTEX
Pallocca GiorgiaPallocca Giorgia, Leist MarcelDOI:10.14573/altex.2207111 RISK-HUNT3R
PMID: 35871507 -
Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation
2022 | Archives of Toxicology
van der Stel Wandavan der Stel Wanda, Yang Huan, Vrijenhoek Nanette G., Schimming Johannes P., Callegaro Giulia, Carta Giada, Darici Salihanur, Delp Johannes, Forsby Anna, White Andrew, le Dévédec Sylvia, Leist Marcel, Jennings Paul, Beltman Joost B, van de Water Bob, Danen ErikDOI:10.1007/s00204-021-03160-7 RISK-HUNT3R
PMID: 34642769 -
Metabolic regulation by p53 prevents R-loop-associated genomic instability
2022 | Cell Reports
Panatta EmanuelePanatta Emanuele, Butera Alessio, Mammarella Eleonora, Pitolli Consuelo, Mauriello Alessandro, Leist Marcel, Knight Richard A., Melino Gerry, Amelio IvanoDOI:10.1016/j.celrep.2022.111568 RISK-HUNT3R
PMID: 36323249 -
SimRFlow: An R-based workflow for automated high-throughput PBPK simulation with the Simcyp® simulator
2022 | Frontiers in Pharmacology
Khalidi HibaKhalidi Hiba, Onasanwo Anthonia, Islam Barira, Jo Heeseung, Fisher Ciarán, Aidley Rich, Gardner Iain, Bois Frederic Y.DOI:10.3389/fphar.2022.929200 RISK-HUNT3R
PMID: 36091744 -
Specific Attenuation of Purinergic Signaling during Bortezomib-Induced Peripheral Neuropathy In Vitro
2022 | International Journal of Molecular Sciences
Holzer Anna-KatharinaHolzer Anna-Katharina, Suciu Ilinca, Karreman Christiaan, Goj Thomas, Leist MarcelDOI:10.3390/ijms23073734 RISK-HUNT3R
PMID: 35409095 -
Studying Metabolism by NMR-Based Metabolomics
2022 | Frontiers in Molecular Biosciences
Moco SofiaDOI:10.3389/fmolb.2022.882487 RISK-HUNT3R
PMID: 35573745 -
On the usefulness of animals as a model system (part I): Overview of criteria and focus on robustness
2022 | ALTEX
Pallocca GiorgiaPallocca Giorgia, Rovida Costanza, Leist MarcelDOI:10.14573/altex.2203291 RISK-HUNT3R
PMID: 35413127 -
Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals
2022 | Chemosphere
Blum JonathanBlum Jonathan, Masjosthusmann Stefan, Bartmann Kristina, Bendt Farina, Dolde Xenia, Dönmez Arif, Förster Nils, Holzer Anna-Katharina, Hübenthal Ulrike, Keßel Hagen Eike, Kilic Sadiye, Klose Jördis, Pahl Melanie, Stürzl Lynn-Christin, Mangas Iris, Terron Andrea, Crofton Kevin M., Scholze Martin, Mosig Axel, Leist Marcel, Fritsche EllenDOI:10.1016/j.chemosphere.2022.137035 RISK-HUNT3R
PMID: 36328314 -
Use of metabolic glycoengineering and pharmacological inhibitors to assess lipid and protein sialylation on cells.
2022 | Journal of Neurochemistry
Kranaster PetraKranaster Petra, Blum Jonathan, Dold Jeremias E G A, Wittmann Valentin, Leist MarcelDOI:10.1111/jnc.15737 RISK-HUNT3R
PMID: 36504018 -
Current Status and Challenges of Human Induced Pluripotent Stem Cell-Derived Liver Models in Drug Discovery
2022 | Cells
Tricot TineTricot Tine, Verfaillie Catherine M, Kumar ManojDOI:10.3390/cells11030442 RISK-HUNT3R
PMID: 35159250 -
High Accuracy Classification of Developmental Toxicants by In Vitro Tests of Human Neuroepithelial and Cardiomyoblast Differentiation
2022 | Cells
Seidel FlorianSeidel Florian, Cherianidou Anna, Kappenberg Franziska, Marta Miriam, Dreser Nadine, Blum Jonathan, Waldmann Tanja, Blüthgen Nils, Meisig Johannes, Madjar Katrin, Henry Margit, Rotshteyn Tamara, Scholtz-Illigens Andreas, Marchan Rosemarie, Edlund Karolina, Leist Marcel, Rahnenführer Jörg, Sachinidis Agapios, Hengstler Jan G.DOI:10.3390/cells11213404 RISK-HUNT3R
PMID: 36359802 -
Optimization of the TeraTox Assay for Preclinical Teratogenicity Assessment
2022 | Toxicological Sciences
Jaklin ManuelaJaklin Manuela, Zhang Jitao David, Schäfer Nicole, Clemann Nicole, Barrow Paul, Küng Erich, Sach-Peltason Lisa, McGinnis Claudia, Leist Marcel, Kustermann StefanDOI:10.1093/toxsci/kfac046 RISK-HUNT3R
PMID: 35485993 -
Guidance document on Good Cell and Tissue Culture Practice 2.0 (GCCP 2.0)
2022 | ALTEX
Pamies DavidPamies David, Leist Marcel, Coecke Sandra, Bowe Gerard, Allen David G., Gstraunthaler Gerhard, Bal-Price Anna, Pistollato Francesca, de Vries Rob B. M., Hogberg Helena T., Hartung ThomasDOI:10.14573/altex.2111011 RISK-HUNT3R
PMID: 34882777 -
Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation
2021 | Archives of Toxicology
van der Stel Wandavan der Stel Wanda, Yang Huan, Vrijenhoek Nanette G, Schimming Johannes P, Callegaro Giulia, Carta Giada, Darici Salihanur, Delp Johannes, Forsby Anna, White Andrew, le Dévédec Sylvia, Leist Marcel, Jennings Paul, Beltman Joost B, van de Water Bob, Danen Erik H JDOI:10.1007/s00204-021-03160-7 RISK-HUNT3R
PMID: 34642769 -
Synuclein Family Members Prevent Membrane Damage by Counteracting α-Synuclein Aggregation
2021 | Biomolecules
Scheibe ChristianScheibe Christian, Karreman Christiaan, Schildknecht Stefan, Leist Marcel, Hauser KarinDOI:10.3390/biom11081067 RISK-HUNT3R
PMID: 34439733 -
New approach methods (NAMs) supporting read-across: Two neurotoxicity AOP-based IATA case studies
2021 | ALTEX - Alternatives to animal experimentation, 38(4), pp. 615–635
van der Stel Wandavan der Stel Wanda, Carta Giada, Eakins Julie, Delp Johannes, Suciu Ilinca, Forsby Anna, Cediel Ulloa Andrea Paola, Attoff Kristina, Troger Florentina, Kamp Hennicke, Gardner Iain, Zdrazil Barbara, Moné Martijn J., Ecker Gerhard F, Pastor Manuel, Gómez-Tamayo José Carlos, White Andrew, Danen Erik, Leist Marcel, Walker Paul, Jennings Paul, Bennekou Suzanne H., van de Water BobDOI:https://doi.org/10.14573/altex.2103051 RISK-HUNT3R
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Flame: An Open Source Framework for Model Development, Hosting, and Usage in Production Environments
2021 | Journal of Cheminformatics
Pastor ManuelPastor Manuel, Gómez-Tamayo José Carlos, Sanz FerranDOI:https://doi.org/10.21203/rs.3.rs-107430/v1 RISK-HUNT3R
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Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling
2021 | Archives of Toxicology
Loser DominikLoser Dominik, Grillberger Karin, Hinojosa Maria G., Blum Jonathan, Hauser Karin, Danker Timm, Johansson Ylva, Möller Clemens, Nicke Annette, Bennekou Suzanne H., Gardner Iain, Bauch Caroline, Walker Paul, Forsby Anna, Ecker Gerhard F, Kraushaar Udo, Leist MarcelDOI:10.1007/s00204-021-03168-z RISK-HUNT3R
PMID: 34628512 -
Profiling of Human Neural Crest Chemoattractant Activity as a Replacement of Fetal Bovine Serum for In Vitro Chemotaxis Assays
2021 | International Journal of Molecular Sciences
Dolde XeniaDolde Xenia, Karreman Christiaan, Wiechers Marianne, Schildknecht Stefan, Leist MarcelDOI:10.3390/ijms221810079 RISK-HUNT3R
PMID: 34576243 -
ATF6 Is a Critical Determinant of CHOP Dynamics during the Unfolded Protein Response
2020 | iScience
Yang HuanYang Huan, Niemeijer Marije, van de Water Bob, Beltman Joost BDOI:10.1016/j.isci.2020.100860 RISK-HUNT3R
PMID: 32058971 -
Analysis of Time-Series Gene Expression Data to Explore Mechanisms of Chemical-Induced Hepatic Steatosis Toxicity
2019 | Frontiers in Genetics
Aguayo-Orozco AlejandroAguayo-Orozco Alejandro, Bois Frederic Y, Brunak Søren, Taboureau OlivierDOI:https://doi.org/10.3389/fgene.2018.00396 RISK-HUNT3R
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Development of a neurotoxicity assay that is tuned to detect mitochondrial toxicants
2019 | Archives of Toxicology
Delp JohannesDelp Johannes, Funke Melina, Rudolf Franziska, Cediel Andrea, Hougaard Bennekou Susanne, van der Stel Wanda, Carta Giada, Jennings Paul, Toma Cosimo, Gardner Iain, van de Water Bob, Forsby Anna, Leist MarcelDOI:10.1007/s00204-019-02473-y RISK-HUNT3R
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Introducing WikiPathways as a Data-Source to Support Adverse Outcome Pathways for Regulatory Risk Assessment of Chemicals and Nanomaterials
2018 | Frontiers in Genetics
Martens MarvinMartens Marvin, Verbruggen Tim, Nymark Penny, Grafström Roland, Burgoon Lyle D., Aladjov Hristo, Torres Andón Fernando, Evelo Chris T., Willighagen Egon L.DOI:10.3389/fgene.2018.00661 RISK-HUNT3R
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A new semi-automated workflow for chemical data retrieval and quality checking for modeling applications
2018 | Journal of Cheminformatics
Gadaleta DomenicoGadaleta Domenico, Lombardo Anna, Toma Cosimo, Benfenati Emilio, Tredwell Gregory D., Wilmes Anja, Aschauer Lydia, Siskos Alexandros P., Sachinidis Agapios, Keun Hector C., Kopp-Schneider Annette, de Kok Theo M., Kleinjans Jos C S, Jennings PaulDOI:10.1186/s13321-018-0315-6 RISK-HUNT3R
PMID: 30536051 -
Persistence of Epigenomic Effects After Recovery From Repeated Treatment With Two Nephrocarcinogens
2018 | Frontiers in Genetics
Limonciel AliceLimonciel Alice, van Breda Simone G J, Jiang XiaoqiDOI:https://doi.org/10.3389/fgene.2018.00558 RISK-HUNT3R
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Investigation of Nrf2, AhR and ATF4 Activation in Toxicogenomic Databases
2018 | Frontiers in Genetics
Zgheib EliasZgheib Elias, Limonciel Alice, Jiang Xiaoqi, Wilmes Anja, Wink Steven, van de Water Bob, Kopp-Schneider Annette, Bois Frederic Y, Jennings PaulDOI:10.3389/fgene.2018.00429 RISK-HUNT3R
PMID: 30333853
Other Output
Other output published by consortium members will be available here.
Coming soon.