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Journal publications
Links to articles published by consortium members will be available here.
Author
All authors
Azeredo Pereira Sofia
Ball Nicholas
Bars Remi
Beltman Joost B
Botham Philip A
Brito Catarina
Callegaro Giulia
Carecho Rafael
Carta Giada
Cronin Mark T D
Cuciureanu Andreea
Danen Erik H J
Darici Salihanur
Delp Johannes
Doe John E
Dudzina Tatsiana
Figueira Inês
Forsby Anna
Gant Timothy W
Godinho-Pereira Joana
Jennings Paul
Leist Marcel
Milenkovic Dragan
Nunes Dos Santos Cláudia
Schimming Johannes P
Terrasso Ana Paul
Vrijenhoek Nanette G
White Andrew
Yang Huan
de Oliveira Sequeira Catarina
le Dévédec Sylvia
van Ravenzwaay Bennard
van de Water Bob
van der Stel Wanda
Year
All years
2021
2022
Journal
All Journal
Molecular nutrition & Food Research
Archives of Toxicology
Altex
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An Adverse Outcome Pathway Network for Chemically Induced Oxidative Stress Leading to (Non)genotoxic Carcinogenesis2023 | Chemical Research in ToxicologyVeltman Christina H. J., Pennings Jeroen L. A., van de Water Bob, Luijten MirjamKeywords: Cancer · Genetics · Oxidative stress · Peptides and proteins · ToxicologyDOI: 10.1021/acs.chemrestox.2c00396 RISK-HUNT3RPMID: 37156502
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Circulating (Poly)phenol Metabolites: Neuroprotection in a 3D Cell Model of Parkinson’s Disease2022 | Molecular nutrition & Food ResearchCarecho Rafael, Figueira Inês, Terrasso Ana Paul, Godinho-Pereira Joana, de Oliveira Sequeira Catarina, Azeredo Pereira Sofia, Milenkovic Dragan, Leist Marcel, Brito Catarina, Nunes Dos Santos CláudiaKeywords: Dopaminergic neurons · Gene expression · Neurodegeneration · Preconditioning · TranscriptomicsDOI: 10.1002/mnfr.202100959 RISK-HUNT3RPMID: 34964254
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A framework for chemical safety assessment incorporating new approach methodologies within REACH2022 | Archives of ToxicologyBall Nicholas, Bars Remi, Botham Philip A, Cuciureanu Andreea, Cronin Mark T D, Doe John E, Dudzina Tatsiana, Gant Timothy W, Leist Marcel, van Ravenzwaay BennardKeywords: Chemical risk assessment · New approach methodology · Regulatory framework · Tiered assessment · ToxicityDOI: 10.1007/s00204-021-03215-9 RISK-HUNT3RPMID: 35103819
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Next-generation risk assessment of chemicals – Rolling out a human-centric testing strategy to drive 3R implementation: The RISK-HUNT3R project perspective2022 | AltexPallocca Giorgia, Moné Martijn J., Kamp Hennicke, Luijten Mirjam, van de Water Bob, Leist MarcelKeywords: Next-generation Risk Assessment · New Approach Methodologies · H2020 Project · RISK-HUNT3RDOI: 10.14573/altex.2204051 RISK-HUNT3RPMID: 35404467
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Specific Attenuation of Purinergic Signaling during Bortezomib-Induced Peripheral Neuropathy In Vitro2022 | International Journal of Molecular SciencesHolzer Anna-Katharina, Suciu Ilinca, Karreman Christiaan, Goj Thomas, Leist MarcelKeywords: Nociceptors · Purinergic Receptor P2X3 · Peripheral Nervous System Diseases · Bortezomib Proteasome InhibitorsDOI: 10.3390/ijms23073734 RISK-HUNT3RPMID: 35409095
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A quantitative AOP of mitochondrial toxicity based on data from three cell lines2022 | Toxicology in VitroTebby Cleo, Wang Gao, Delp Johannes, Carta Giada, van der Stel Wanda, Leist Marcel, Jennings Paul, van de Water Bob, Bois Frederic YKeywords:DOI: 10.1016/j.tiv.2022.105345 RISK-HUNT3RPMID: 35278637
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Specific attenuation of purinergic signaling during bortezomib-induced peripheral neuropathy2022 | International Journal of Molecular SciencesHolzer Anna-Katharina, Suciu Ilinca, Goj Thomas, Karreman Christiaan, Leist MarcelKeywords:DOI: 10.1101/2022.02.17.479688 RISK-HUNT3RPMID: 35409095
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Zebrafish embryo neonicotinoid developmental neurotoxicity in the FET test and behavioral assays2022 | ALTEXvon Hellfeld Rebecca, Ovcharova Viktoriia, Bevan Samantha, Lazaridi Maria-Agapi, Bauch Caroline, Walker Paul, Hougaard Bennekou Susanne, Forsby Anna, Braunbeck ThomasKeywords:DOI: 10.14573/altex.2111021 RISK-HUNT3R
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Application of high-throughput transcriptomics for mechanism-based biological read-across of short-chain carboxylic acid analogues of valproic acid2022 | ALTEXVrijenhoek Nanette G., Wehr Matthias, Kunnen Steven J., Wijaya Lukas S., Callegaro Giulia, Moné Martijn J., Escher Sylvia E., van de Water BobKeywords:DOI: 10.14573/altex.2107261 RISK-HUNT3R
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Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation2022 | Archives of Toxicologyvan der Stel Wanda, Yang Huan, Vrijenhoek Nanette G., Schimming Johannes P., Callegaro Giulia, Carta Giada, Darici Salihanur, Delp Johannes, Forsby Anna, White Andrew, le Dévédec Sylvia, Leist Marcel, Jennings Paul, Beltman Joost B, van de Water Bob, Danen ErikKeywords: Mitochondrial toxicity ETC complex inhibitors High-content imaging TempO-Seq DILIDOI: 10.1007/s00204-021-03160-7 RISK-HUNT3R
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Classification of Developmental Toxicants in a Human iPSC Transcriptomics-Based Test2022 | Chemical Research in ToxicologyCherianidou Anna, Seidel Florian, Kappenberg Franziska, Dreser Nadine, Blum Jonathan, Blüthgen Nils, Edlund Karolina, Henry Margit, Leist Marcel, Madjar Katrin, Marchan Rosemarie, Meisig Johannes, Rahnenführer Jörg, Rotshteyn Tamara, Sachinidis Agapios, Waldmann Tanja, Hengstler Jan G.Keywords: Antineoplastic agents · Genetics · Inhibitors · ProbesToxicityDOI: 10.1021/acs.chemrestox.1c00392 RISK-HUNT3RPMID: 35416653
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Distinct and Dynamic Transcriptome Adaptations of iPSC-Generated Astrocytes after Cytokine Stimulation2022 | CellsSpreng Anna-Sophie, Brüll Markus, Leisner Heidrun, Suciu Ilinca, Leist MarcelKeywords: Astrocytes · Cytokines · Dynamic transcriptome changes · iPSC · InflammationDOI: 10.3390/cells11172644 RISK-HUNT3RPMID: 36078052
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Generation of Human Nociceptor-Enriched Sensory Neurons for the Study of Pain-Related Dysfunctions2022 | Stem CellsHolzer Anna-Katharina, Karreman Christiaan, Furmanowsky Lara-Seline, Wohlfarth Harald, Loser Dominik, Dirks Wilhelm G., González Emilio Pardo, Leist MarcelKeywords: TRPV cation channels · Allodynia · Nociceptors · Oxaliplatin · Peripheral nervous system diseases · Purinergic P2X3 · ReceptorsDOI: 10.1093/stcltm/szac031 RISK-HUNT3RPMID: 35689659
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On the Usefulness of Animals as a Model System (Part II): Considering Benefits within Distinct Use Domains2022 | ALTEXPallocca Giorgia, Leist MarcelKeywords: BenchMarks series · Net benefit model · Performance validation · Use domainDOI: 10.14573/altex.2207111 RISK-HUNT3RPMID: 35871507
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Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation2022 | Archives of Toxicologyvan der Stel Wanda, Yang Huan, Vrijenhoek Nanette G., Schimming Johannes P., Callegaro Giulia, Carta Giada, Darici Salihanur, Delp Johannes, Forsby Anna, White Andrew, le Dévédec Sylvia, Leist Marcel, Jennings Paul, Beltman Joost B, van de Water Bob, Danen ErikKeywords: Mitochondrial toxicity ETC complex inhibitors High-content imaging TempO-Seq DILIDOI: 10.1007/s00204-021-03160-7 RISK-HUNT3R
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Metabolic regulation by p53 prevents R-loop-associated genomic instability2022 | Cell ReportsPanatta Emanuele, Butera Alessio, Mammarella Eleonora, Pitolli Consuelo, Mauriello Alessandro, Leist Marcel, Knight Richard A., Melino Gerry, Amelio IvanoKeywords: CP: Molecular biology · Cancer · Chromosome stability · Epigenetic integrity · p53 · Tumor suppressionDOI: 10.1016/j.celrep.2022.111568 RISK-HUNT3RPMID: 36323249
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SimRFlow: An R-based workflow for automated high-throughput PBPK simulation with the Simcyp® simulator2022 | Frontiers in PharmacologyKhalidi Hiba, Onasanwo Anthonia, Islam Barira, Jo Heeseung, Fisher Ciarán, Aidley Rich, Gardner Iain, Bois Frederic Y.Keywords: PBPK modelling · R · Automated data collection · High-throughput · Modular workflow · Pharmacokinetics · Simcyp simulator · SimulationDOI: 10.3389/fphar.2022.929200 RISK-HUNT3RPMID: 36091744
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Specific Attenuation of Purinergic Signaling during Bortezomib-Induced Peripheral Neuropathy In Vitro2022 | International Journal of Molecular SciencesHolzer Anna-Katharina, Suciu Ilinca, Karreman Christiaan, Goj Thomas, Leist MarcelKeywords: Bortezomib · Nociceptors · Peripheral nervous system diseases · Proteasome inhibitors · Purinergic receptor P2X3DOI: 10.3390/ijms23073734 RISK-HUNT3RPMID: 35409095
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Studying Metabolism by NMR-Based Metabolomics2022 | Frontiers in Molecular BiosciencesMoco SofiaKeywords: NMR · Metabolism · Metabolite-protein interactions · Metabolomics ·qNMR · Stable isotopesDOI: 10.3389/fmolb.2022.882487 RISK-HUNT3RPMID: 35573745
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On the usefulness of animals as a model system (part I): Overview of criteria and focus on robustness2022 | ALTEXPallocca Giorgia, Rovida Costanza, Leist MarcelKeywords: Benchmark series · Robustness · Applicability domain · Success criteriaDOI: 10.14573/altex.2203291 RISK-HUNT3RPMID: 35413127
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Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals2022 | ChemosphereBlum Jonathan, Masjosthusmann Stefan, Bartmann Kristina, Bendt Farina, Dolde Xenia, Dönmez Arif, Förster Nils, Holzer Anna-Katharina, Hübenthal Ulrike, Keßel Hagen Eike, Kilic Sadiye, Klose Jördis, Pahl Melanie, Stürzl Lynn-Christin, Mangas Iris, Terron Andrea, Crofton Kevin M., Scholze Martin, Mosig Axel, Leist Marcel, Fritsche EllenKeywords: Brain development · DNT · In vitro testing · Stem cell · Testing batteryDOI: 10.1016/j.chemosphere.2022.137035 RISK-HUNT3RPMID: 36328314
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Use of metabolic glycoengineering and pharmacological inhibitors to assess lipid and protein sialylation on cells.2022 | Journal of NeurochemistryKranaster Petra, Blum Jonathan, Dold Jeremias E G A, Wittmann Valentin, Leist MarcelKeywords: Confocal imaging · Ganglioside · Metabolic glycoengineering · Neural cell adhesion molecule · Neuron · Polysialic acid · Salic acidDOI: 10.1111/jnc.15737 RISK-HUNT3RPMID: 36504018
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Current Status and Challenges of Human Induced Pluripotent Stem Cell-Derived Liver Models in Drug Discovery2022 | CellsTricot Tine, Verfaillie Catherine M, Kumar ManojKeywords: Liver disease modeling · Stem cell-derived hepatocyte-like cellsDOI: 10.3390/cells11030442 RISK-HUNT3RPMID: 35159250
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High Accuracy Classification of Developmental Toxicants by In Vitro Tests of Human Neuroepithelial and Cardiomyoblast Differentiation2022 | CellsSeidel Florian, Cherianidou Anna, Kappenberg Franziska, Marta Miriam, Dreser Nadine, Blum Jonathan, Waldmann Tanja, Blüthgen Nils, Meisig Johannes, Madjar Katrin, Henry Margit, Rotshteyn Tamara, Scholtz-Illigens Andreas, Marchan Rosemarie, Edlund Karolina, Leist Marcel, Rahnenführer Jörg, Sachinidis Agapios, Hengstler Jan G.Keywords: Alternative testing strategies · Developmental and reproductive toxicity · Drug screening · Gene expression · In vitro test · Induced pluripotent stem cells · Toxicogenomics · TranscriptomicsDOI: 10.3390/cells11213404 RISK-HUNT3RPMID: 36359802
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Optimization of the TeraTox Assay for Preclinical Teratogenicity Assessment2022 | Toxicological SciencesJaklin Manuela, Zhang Jitao David, Schäfer Nicole, Clemann Nicole, Barrow Paul, Küng Erich, Sach-Peltason Lisa, McGinnis Claudia, Leist Marcel, Kustermann StefanKeywords: TeraTox · Embryoid bodies · Factor analysis · Machine learning · Molecular phenotyping · TeratogenicityDOI: 10.1093/toxsci/kfac046 RISK-HUNT3RPMID: 35485993
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Guidance document on Good Cell and Tissue Culture Practice 2.0 (GCCP 2.0)2022 | ALTEXPamies David, Leist Marcel, Coecke Sandra, Bowe Gerard, Allen David G., Gstraunthaler Gerhard, Bal-Price Anna, Pistollato Francesca, de Vries Rob B. M., Hogberg Helena T., Hartung ThomasKeywords: Cell models · Cell culture · Good Cell and Tissue Culture Practice · GCCPDOI: 10.14573/altex.2111011 RISK-HUNT3RPMID: 34882777
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Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation2021 | Archives of Toxicologyvan der Stel Wanda, Yang Huan, Vrijenhoek Nanette G, Schimming Johannes P, Callegaro Giulia, Carta Giada, Darici Salihanur, Delp Johannes, Forsby Anna, White Andrew, le Dévédec Sylvia, Leist Marcel, Jennings Paul, Beltman Joost B, van de Water Bob, Danen Erik H JKeywords: Mitochondrial toxicity · ETC complex inhibitors · High-content imaging · TempO-Seq · DILIDOI: 10.1007/s00204-021-03160-7 RISK-HUNT3RPMID: 34642769
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Synuclein Family Members Prevent Membrane Damage by Counteracting α-Synuclein Aggregation2021 | BiomoleculesScheibe Christian, Karreman Christiaan, Schildknecht Stefan, Leist Marcel, Hauser KarinKeywords: Polarized ATR-FTIR · Protein–membrane Interaction · Protein–protein Interaction · Alpha-synuclein · Beta-synucleinDOI: 10.3390/biom11081067 RISK-HUNT3RPMID: 34439733
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Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling2021 | Archives of ToxicologyLoser Dominik, Grillberger Karin, Hinojosa Maria G., Blum Jonathan, Hauser Karin, Danker Timm, Johansson Ylva, Möller Clemens, Nicke Annette, Bennekou Suzanne H., Gardner Iain, Bauch Caroline, Walker Paul, Forsby Anna, Ecker Gerhard F, Kraushaar Udo, Leist MarcelKeywords:DOI: 10.1007/s00204-021-03168-z RISK-HUNT3R
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New approach methods (NAMs) supporting read-across: Two neurotoxicity AOP-based IATA case studies2021 | ALTEX - Alternatives to animal experimentation, 38(4), pp. 615–635van der Stel Wanda, Carta Giada, Eakins Julie, Delp Johannes, Suciu Ilinca, Forsby Anna, Cediel Ulloa Andrea Paola, Attoff Kristina, Troger Florentina, Kamp Hennicke, Gardner Iain, Zdrazil Barbara, Moné Martijn J., Ecker Gerhard F, Pastor Manuel, Gómez-Tamayo José Carlos, White Andrew, Danen Erik, Leist Marcel, Walker Paul, Jennings Paul, Bennekou Suzanne H., van de Water BobKeywords: in vitro mitochondrial toxicity neurotoxicity PBK-modelling uncertainty analysisDOI: https://doi.org/10.14573/altex.2103051 RISK-HUNT3R
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The in vitro assessment of the toxicity of volatile, oxidisable, redox-cycling compounds: phenols as an example2021 | Archives of Toxicology volume 95, pages2109–2121 (2021)Tolosa Laia, Martinez-Sena Teresa, Schimming Johannes P., Moro Erika, Escher Sylvia E., ter Braak Bas, van de Water Bob, Miranda M. A., van Vugt-Lussenburg Barbara M A, Castell Jose VKeywords: Toxicity of phenols; Redox-cycling phenols; In vitro toxicity; Hepatotoxicity; Cross-contamination of culture wells; Plastic seals; High-content imaging; HepG2 BAC-GFP SRXN1 assay; Nrf2 CALUX reporter gene assay; Cytotox CALUX reporter gene assayDOI: https://doi.org/10.1007/s00204-021-03036-w RISK-HUNT3R
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Generation and characterization of iPSC-derived renal proximal tubule-like cells with extended stability2021 | Scientific Reports volume 11, Article number: 11575 (2021)Chandrasekaran Vidya, Carta Giada, da Costa Pereira Daniel, Gupta Rajinder, Murphy Cormac, Feifel Elisabeth, Kern Georg, Lechner Judith, Cavallo Anna Lina, Gupta Shailesh, Caiment Florian, Kleinjans Jos C S, Gstraunthaler Gerhard, Jennings Paul, Wilmes AnjaKeywords: Cell biology; Stem cellsDOI: https://doi.org/10.1038/s41598-021-89550-4 RISK-HUNT3R
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Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery2021 | Cell Biology and Toxicology (2021)Klose Jördis, Pahl Melanie, Bartmann Kristina, Bendt Farina, Blum Jonathan, Dolde Xenia, Förster Nils, Holzer Anna-Katharina, Hübenthal Ulrike, Keßel Hagen Eike, Koch Katharina, Masjosthusmann Stefan, Schneider Sabine, Stürzl Lynn-Christin, Woeste Selina, Rossi Andrea, Covaci Adrian, Behl Mamta, Leist Marcel, Tigges Julia, Fritsche EllenKeywords: Developmental neurotoxicity; Flame retardants; Human cell–based testing battery; 3D in vitro model; New approach methodologies; Hazard assessmentDOI: https://doi.org/10.1007/s10565-021-09603-2 RISK-HUNT3R
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Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes2021 | Cell Biology and Toxicology (2021)Wijaya Lukas S., Rau Carina, Braun Theresa S., Marangoz Serif, Spegg Vincent, Vlasveld Matthijs, Albrecht Wiebke, Brecklinghaus Tim, Kamp Hennicke, Beltman Joost B, Hengstler Jan G., van de Water Bob, Leist Marcel, Schildknecht StefanKeywords: Nitrofurantoin; Hepatocytes; Nrf2; Glutathione; Cytochrome P450 reductaseDOI: https://doi.org/10.1007/s10565-021-09610-3 RISK-HUNT3R
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Integration of temporal single cell cellular stress response activity with logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver injury2021 | Biochemical PharmacologyWijaya Lukas S., Trairatphisan Panuwat, Gabor Attila, Niemeijer Marije, Keet Jason, Alcalà Morera Ariadna, Snijders Kirsten E., Wink Steven, Yang Huan, Schildknecht Stefan, Stevens James L., Bouwman Peter, Kamp Hennicke, Hengstler Jan G., Beltman Joost B, Leist Marcel, le Dévédec Sylvia, Saez-Rodriguez Julio, van de Water BobKeywords: GFP-reporter; Logic-ODE; Stress response pathway; Drug-induced liver injury (DILI)DOI: https://doi.org/10.1016/j.bcp.2021.114591 RISK-HUNT3R
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A human stem cell-derived test system for agents modifying neuronal N-methyl-D-aspartate-type glutamate receptor Ca2+-signalling2021 | Archives of Toxicology volume 95, pages 1703–1722 (2021)Klima Stefanie, Brüll Markus, Spreng Anna-Sophie, Suciu Ilinca, Falt Tjalda, Schwamborn Jens C., Waldmann Tanja, Karreman Christiaan, Leist MarcelKeywords: Ketamine; MEA; Phencyclidine; Dextromethorphan; Domoic acid; Neurotoxicity; Ibotenic acidDOI: https://doi.org/10.1007/s00204-021-03024-0 RISK-HUNT3R
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Physiologically Relevant Estrogen Receptor Alpha Pathway Reporters for Single-Cell Imaging-Based Carcinogenic Hazard Assessment of Estrogenic Compounds2021 | Toxicological Sciences, Volume 181, Issue 2, June 2021, Pages 187–198Duijndam Britt, Goudriaan Annabel, van den Hoorn Tineke, van der Stel Wanda, le Dévédec Sylvia, Bouwman Peter, van der Laan Jan Willem, van de Water BobKeywords: Estrogen receptor alpha, fluorescent reporters, live-cell imaging, single cellDOI: https://doi.org/10.1093/toxsci/kfab037 RISK-HUNT3R
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Systematic transcriptome-based comparison of cellular adaptive stress response activation networks in hepatic stem cell-derived progeny and primary human hepatocytes2021 | Toxicology in Vitroter Braak Bas, Niemeijer Marije, Boon Ruben, Parmentier Céline, Baze Audrey, Richert Lysiane, Huppelschoten Suzanna, Wink Steven, Verfaillie Catherine M, van de Water BobKeywords:DOI: 10.1016/j.tiv.2021.105107 RISK-HUNT3R
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Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons2021 | Archives of Toxicology volume 95, pages 2081–2107 (2021)Loser Dominik, Hinojosa Maria G., Blum Jonathan, Schaefer Jasmin, Brüll Markus, Johansson Ylva, Suciu Ilinca, Grillberger Karin, Danker Timm, Möller Clemens, Gardner Iain, Ecker Gerhard F, Bennekou Suzanne H., Forsby Anna, Kraushaar Udo, Leist MarcelKeywords: Live-cell calcium imaging; Neurotoxicity; Nicotine; Desensitization; Molecular dockingDOI: https://doi.org/10.1007/s00204-021-03031-1 RISK-HUNT3R
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Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling2021 | Archives of ToxicologyLoser Dominik, Grillberger Karin, Hinojosa Maria G., Blum Jonathan, Hauser Karin, Danker Timm, Johansson Ylva, Möller Clemens, Nicke Annette, Bennekou Suzanne H., Gardner Iain, Bauch Caroline, Walker Paul, Forsby Anna, Ecker Gerhard F, Kraushaar Udo, Leist MarcelKeywords: Developmental neurotoxicity; Live-cell calcium imaging; Molecular docking; Nicotine; Oocyte recording; Pesticide metabolism.DOI: 10.1007/s00204-021-03168-z RISK-HUNT3RPMID: 34628512
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Profiling of Human Neural Crest Chemoattractant Activity as a Replacement of Fetal Bovine Serum for In Vitro Chemotaxis Assays2021 | International Journal of Molecular SciencesDolde Xenia, Karreman Christiaan, Wiechers Marianne, Schildknecht Stefan, Leist MarcelKeywords: Cell migration · Chemotaxis · Fetal bovine serum · Human platelet lysate · Neural crest cellsDOI: 10.3390/ijms221810079 RISK-HUNT3RPMID: 34576243
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Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment2020 | Environment InternationalDrakvik Paula E, Altenburger Rolf, Aoki Yasunobu, Backhaus Thomas, Bahadori Tina, Barouki Robert, Brack Werner, Cronin Mark T. D., Demeneix Barbara, Bennekou Suzanne H., van Klaveren Jacob, Kneuer Carsten, Kolossa-Gehring Marike, Lebret Erik, Posthuma Leo, Reiber Lena, Rider Cynthia, Ruegg Joelle, Testa Giuseppe, van der Burg Bart, van der Voet Hilko, Warhurst A. Michael, van de Water Bob, Yamazaki Kunihiko, Öberg Mattias, Bergman ÅkeKeywords:DOI: 10.1016/j.envint.2019.105267 RISK-HUNT3R
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Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals2020 | Archives of Toxicologyvan der Stel Wanda, Carta Giada, Eakins Julie, Darici Salihanur, Delp Johannes, Forsby Anna, Hougaard Bennekou Susanne, Gardner Iain, Leist Marcel, Danen Erik H J, Walker Paul, van de Water Bob, Jennings PaulKeywords:DOI: 10.1007/s00204-020-02792-5 RISK-HUNT3RPMID: 32607615
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Determination of benchmark concentrations and their statistical uncertainty for cytotoxicity test data and functional in vitro assays2020 | AltexKrebs Alice, Nyffeler Johanna, Karreman Christiaan, Schmidt Béla Z., Mellert Werner, Pallocca Giorgia, Pastor Manuel, Rahnenführer Jörg, Leist MarcelKeywords:DOI: https://doi.org/10.14573/altex.1912021 RISK-HUNT3R
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Harnessing the power of novel animal-free test methods for the development of COVID-19 drugs and vaccines2020 | Archives of ToxicologyBusquet Francois, Hartung Thomas, Pallocca Giorgia, Rovida Costanza, Leist MarcelKeywords:DOI: 10.1007/s00204-020-02787-2 RISK-HUNT3RPMID: 32447523
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The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods2020 | Archives of ToxicologyKrebs Alice, van Vugt-Lussenburg Barbara M A, Waldmann Tanja, Albrecht Wiebke, Boei Jan J, ter Braak Bas, Brajnik Maja, Braunbeck Thomas, Brecklinghaus Tim, Exner Thomas, Fisher Ciarán, Fluri David A, Forsby Anna, Hengstler Jan G., Holzer Anna-Katharina, Janstova Zofia, Jennings Paul, Kisitu Jaffar, Kobolák Julianna, Kumar Manoj, Limonciel Alice, Lundqvist Jessica, Mihalik Balázs, Moritz Wolfgang, Pallocca Giorgia, Cediel Ulloa Andrea Paola, Pastor Manuel, Rovida Costanza, Sarkans Ugis, Schimming Johannes P, Schmidt Béla Z., Stoeber Regina, Strassfeld Tobias, van de Water Bob, Wilmes Anja, van der Burg Bart, Verfaillie Catherine M, von Hellfeld Rebecca, Vrieling Harry, Vrijenhoek Nanette G, Leist MarcelKeywords:DOI: 10.1007/s00204-020-02802-6 RISK-HUNT3RPMID: 32632539
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Design and evaluation of bi-functional iron chelators for protection of dopaminergic neurons from toxicants2020 | Archives of ToxicologyGutbier Simon, Kyriakou Sotiris, Schildknecht Stefan, Ückert Anna-Katharina, Brüll Markus, Lewis Frank, Dickens David, Pearson Liam, Elson Joanna L., Michel Sylvia, Hubscher-Bruder Véronique, Brandel Jeremy, Tetard David, Leist Marcel, Pienaar Ilse S.Keywords:DOI: 10.1007/s00204-020-02826-y RISK-HUNT3RPMID: 32607613
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Incorporation of stem cell-derived astrocytes into neuronal organoids to allow neuro-glial interactions in toxicological studies2020 | AltexBrüll Markus, Spreng Anna-Sophie, Gutbier Simon, Loser Dominik, Krebs Alice, Reich Marvin, Kraushaar Udo, Britschgi Markus, Patsch Christoph, Leist MarcelKeywords:DOI: https://doi.org/10.14573/altex.1911111 RISK-HUNT3RPMID: 32150624
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ATF6 Is a Critical Determinant of CHOP Dynamics during the Unfolded Protein Response2020 | iScienceYang Huan, Niemeijer Marije, van de Water Bob, Beltman Joost BKeywords:DOI: 10.1016/j.isci.2020.100860 RISK-HUNT3RPMID: 32058971
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Towards grouping concepts based on new approach methodologies in chemical hazard assessment: the read-across approach of the EU-ToxRisk project2019 | Archives of ToxicologyEscher Sylvia E., Kamp Hennicke, Bennekou Suzanne H., Bitsch Annette, Fisher Ciarán, Graepel Rabea, Hengstler Jan G., Herzler Matthias, Knight Derek, Leist Marcel, Norinder Ulf, Ouedraogo Gladys, Pastor Manuel, Stuard Sharon B., White Andrew, Zdrazil Barbara, van de Water Bob, Kroese E. DinantKeywords:DOI: 10.1007/s00204-019-02591-7 RISK-HUNT3R
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Optimizing drug discovery by investigative toxicology: Current and future trends2019 | ALTEX - Alternatives to animal experimentationBeilmann Mario, Boonen Harrie, Czich Andreas, Dear Gordon, Hewitt Philip, Mow Tomas, Newham Peter, Oinonen Teija, Pognan François, Roth Adrian, Valentin Jean-Pierre, Van Goethem Freddy, Weaver Richard, Birk Barbara, Boyer Scott, Caloni Francesca, Chen Alice, Corvi Raffaella, Cronin Mark T. D., Daneshian Mardas, Ewart Lorna, Fitzgerald Rex, Hamilton Geraldine, Hartung Thomas, Kangas Joshua, Kramer Nynke I., Leist Marcel, Marx Uwe, Polak Sebastian, Rovida Costanza, Testai Emanuela, van de Water Bob, Vulto Paul, Steger-Hartmann ThomasKeywords: AOP microphysiological systems drug safety predictive tools risk assessmentDOI: 10.14573/altex.1808181 RISK-HUNT3R
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A systematic analysis of Nrf2 pathway activation dynamics during repeated xenobiotic exposure2019 | Archives of ToxicologyBischoff Luc J. M., Kuijper Isoude A, Schimming Johannes P, Wolters Liesanne, ter Braak Bas, Langenberg Jan P., Noort Daan, Beltman Joost B, van de Water BobKeywords: Nrf2; Srxn1; Repeated exposure; HepG2; Oxidative stress; Soft electrophilesDOI: https://doi.org/10.1007/s00204-018-2353-2 RISK-HUNT3R
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Current EU research activities on combined exposure to multiple chemicals2019 | Environment InternationalBopp Stephanie K, Barouki Robert, Brack Werner, Dalla Costa Silvia, Dorne Jean Lou, Drakvik Paula E, Faust Michael, Karjalainen Tuomo K, Kephalopoulos Stylianos, van Klaveren Jacob, Kolossa-Gehring Marike, Kortenkamp Andreas, Lebret Erik, Lettieri Teresa, Nørager Sofie, Ruegg Joelle, Tarazona Jose V, Trier Xenia, van de Water Bob, van Gils Jos, Bergman ÅkeKeywords:DOI: 10.1016/j.envint.2018.07.037 RISK-HUNT3R
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Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury2019 | Archives of ToxicologyCopple Ian M., den Hollander Wouter, Callegaro Giulia, Mutter Fiona E., Maggs James L., Schofield Amy L., Rainbow Lucille, Fang Yongxiang, Sutherland Jeffrey J., Ellis Ewa C., Ingelman-Sundberg Magnus, Fenwick Stephen W., Goldring Christopher E., van de Water Bob, Stevens James L., Park B. KevinKeywords:DOI: 10.1007/s00204-018-2354-1 RISK-HUNT3R
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Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes2019 | Archives of Toxicology volume 92, pages 3517–3533 (2018)Grinberg Marianna, Stoeber Regina, Albrecht Wiebke, Edlund Karolina, Schug Markus, Godoy Patricio, Cadenas Cristina, Marchan Rosemarie, Lampen Alfonso, Braeuning Albert, Buhrke Thorsten, Leist Marcel, Oberemm Axel, Hellwig Birte, Kamp Hennicke, Gardner Iain, Escher Sylvia E., Taboureau Olivier, Aguayo-Orozco Alejandro, Sachinidis Agapios, Ellinger-Ziegelbauer Heidrun, Rahnenführer Jörg, Hengstler Jan G.Keywords: Rat liver; Cultivated hepatocytes; Hepatotoxicity; Ranking analysis; Batch effect correction; BioinformaticsDOI: 10.1007/s00204-018-2352-3 RISK-HUNT3R
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Application of three approaches for quantitative AOP development to renal toxicity2019 | Computational ToxicologyZgheib Elias, Wang Gao, Limonciel Alice, Aladjov Hristo, Yang Huan, Tebby Cleo, Gayraud Ghislaine, Jennings Paul, Sachana Magdalini, Beltman Joost B, Bois Frederic YKeywords:DOI: 10.1016/j.comtox.2019.02.001 RISK-HUNT3R
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Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations2019 | Archives of ToxicologyAlbrecht Wiebke, Kappenberg Franziska, Brecklinghaus Tim, Stoeber Regina, Marchan Rosemarie, Zhang Mian, Ebbert Kristina, Grinberg Marianna, Leist Marcel, Moritz Wolfgang, Cadenas Cristina, Ghallab Ahmed, Reinders Jörg, Vartak Nachiket, van Thriel Christoph, Golka Klaus, Tolosa Laia, Castell Jose V, Damm Georg, Seehofer Daniel, Lampen Alfonso, Braeuning Albert, Buhrke Thorsten, Behr Anne-Cathrin, Oberemm Axel, Gu Xiaolong, Kittana Naim, van de Water Bob, Kreiling Reinhard, Fayyaz Susann, van Aerts Leon, Smedsrød Bård, Ellinger-Ziegelbauer Heidrun, Steger-Hartmann Thomas, Gundert-Remy Ursula, Zeigerer Anja, Ullrich Anett, Runge Dieter, Lee Serene M. L., Schiergens Tobias S., Kuepfer Lars, Aguayo-Orozco Alejandro, Sachinidis Agapios, Edlund Karolina, Gardner Iain, Rahnenführer Jörg, Hengstler Jan G.Keywords:DOI: 10.1007/s00204-019-02492-9 RISK-HUNT3R
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Development of a neurotoxicity assay that is tuned to detect mitochondrial toxicants2019 | Archives of ToxicologyDelp Johannes, Funke Melina, Rudolf Franziska, Cediel Andrea, Hougaard Bennekou Susanne, van der Stel Wanda, Carta Giada, Jennings Paul, Toma Cosimo, Gardner Iain, van de Water Bob, Forsby Anna, Leist MarcelKeywords:DOI: 10.1007/s00204-019-02473-y RISK-HUNT3R
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Paradigm shift in safety assessment using new approach methods: The EU-ToxRisk strategy2019 | Current Opinion in Toxicology Volume 15, June 2019, Pages 33-39Graepel Rabea, ter Braak Bas, Escher Sylvia E., Fisher Ciarán, Gardner Iain, Kamp Hennicke, Kroese E. Dinant, Leist Marcel, Moné Martijn J., Pastor Manuel, van de Water BobKeywords:DOI: 10.1016/j.cotox.2019.03.005 RISK-HUNT3R
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Chemical concentrations in cell culture compartments (C5) – concentration definitions2019 | ALTEXKisitu Jaffar, Hougaard Bennekou Susanne, Leist MarcelKeywords:DOI: 10.14573/altex.1901031 RISK-HUNT3R
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System Microscopy of Stress Response Pathways in Cholestasis Research2019 | Methods in Molecular BiologySchimming Johannes P., ter Braak Bas, Niemeijer Marije, Wink Steven, van de Water BobKeywords:DOI: 10.1007/978-1-4939-9420-5_13 RISK-HUNT3R
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SUIKER: Quantification of antigens in cell organelles, neurites and cellular sub-structures by imaging2019 | ALTEXKarreman Christiaan, Kranaster Petra, Leist MarcelKeywords:DOI: 10.14573/altex.1906251 RISK-HUNT3R
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Finding synergies for the 3Rs – Repeated Dose Toxicity testing: Report from an EPAA Partners' Forum2019 | Regulatory Toxicology and Pharmacology Volume 108, November 2019, 104470Laroche Charles, Annys Erwin, Bender Hans, Botelho Danielle, Botham Philip, Brendler-Schwaab Susanne, Clayton Rick, Covaro Marco, Dal Negro Gianni, Delannois Frédérique, Dent Matt, Desaintes Christian, Desprez Bertrand, Dhalluin Stephane, Hartmann Andreas, Hoffmann-Doerr Simone, Hubesch Bruno, Irizar Amaia, Manou Irene, Müller Boris P., Nadzialek Stephanie, Prieto Pilar, Rasenberg Mike, Roggeband Rob, Rowan Tim G., Schutte Katrin, van de Water Bob, Westmoreland Carl, Whelan Maurice, Wilschut Annette, Zvonimir Zvonar, Cronin Mark T. D.Keywords:DOI: 10.1016/j.yrtph.2019.104470 RISK-HUNT3R
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High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability2019 | Archives of Toxicology volume 93, pages 2895–2911 (2019)Hiemstra Steven, Ramaiahgari Sreenivasa C., Wink Steven, Callegaro Giulia, Meerman John, Jennen Danyel, van den Nieuwendijk Karen, Dankers Anita, Snoeys Jan, de Bont Hans, Price Leo, van de Water BobKeywords:DOI: 10.1007/s00204-019-02552-0 RISK-HUNT3R
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Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data2019 | ALTEXKrebs Alice, Waldmann Tanja, Wilks Martin F, van Vugt-Lussenburg Barbara M A, van der Burg Bart, Terron Andrea, Steger-Hartmann Thomas, Ruegg Joelle, Rovida Costanza, Pedersen Emma, Pallocca Giorgia, Luijten Mirjam, Leite Sofia B., Kustermann Stefan, Kamp Hennicke, Hoeng Julia, Hewitt Philip, Herzler Matthias, Hengstler Jan G., Heinonen Tuula, Hartung Thomas, Hardy Barry, Gantner Florian, Fritsche Ellen, Fant Kristina, Ezendam Janine, Exner Thomas, Dunkern Torsten, Dietrich Daniel R., Coecke Sandra, Busquet Francois, Braeuning Albert, Bondarenko Olesja, Bennekou Suzanne H., Beilmann Mario, Leist MarcelKeywords:DOI: 10.14573/altex.1909271 RISK-HUNT3R
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Development of a neural rosette formation assay (RoFA) to identify neurodevelopmental toxicants and to characterize their transcriptome disturbances2019 | Archives of ToxicologyDreser Nadine, Madjar Katrin, Holzer Anna-Katharina, Kapitza Marion, Scholz Christopher, Kranaster Petra, Gutbier Simon, Klima Stefanie, Kolb David, Dietz Christian, Trefzer Timo, Meisig Johannes, van Thriel Christoph, Henry Margit, Berthold Michael R., Blüthgen Nils, Sachinidis Agapios, Rahnenführer Jörg, Hengstler Jan G., Waldmann Tanja, Leist MarcelKeywords:DOI: 10.1007/s00204-019-02612-5 RISK-HUNT3R
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Time and space-resolved quantification of plasma membrane sialylation for measurements of cell function and neurotoxicity2019 | Archives of ToxicologyKranaster Petra, Karreman Christiaan, Dold Jeremias E G A, Krebs Alice, Funke Melina, Holzer Anna-Katharina, Klima Stefanie, Nyffeler Johanna, Helfrich Stefan, Wittmann Valentin, Leist MarcelKeywords:DOI: 10.1007/s00204-019-02642-z RISK-HUNT3RPMID: 31828357
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Prevention of neuronal apoptosis by astrocytes through thiol-mediated stress response modulation and accelerated recovery from proteotoxic stress2018 | Cell Death & Differentiation volume 25, pages 2101–2117 (2018)Gutbier Simon, Spreng Anna-Sophie, Delp Johannes, Schildknecht Stefan, Karreman Christiaan, Suciu Ilinca, Brunner Thomas, Groettrup Marcus, Leist MarcelKeywords:DOI: 10.1038/s41418-018-0229-x RISK-HUNT3R
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Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds2018 | npj Systems Biology and ApplicationsOppelt Angela, Kaschek Daniel, Huppelschoten Suzanna, Sison-Young Rowena, Zhang Fang, Buck-Wiese Marie, Herrmann Franziska, Malkusch Sebastian, Krüger Carmen L., Meub Mara, Merkt Benjamin, Zimmermann Lea, Schofield Amy L., Jones Robert P., Malik Hassan, Schilling Marcel, Heilemann Mike, van de Water Bob, Goldring Christopher E., Park B. Kevin, Timmer Jens, Klingmüller UrsulaKeywords:DOI: 10.1038/s41540-018-0058-z RISK-HUNT3RPMID: 29900006
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Advanced Good Cell Culture Practice for human primary, stem cell-derived and organoid models as well as microphysiological systems2018 | ALTEXPamies David, Bal-Price Anna, Chesne Christophe, Coecke Sandra, Dinnyés András, Eskes Chantra, Grillari Regina, Gstraunthaler Gerhard, Hartung Thomas, Jennings Paul, Leist Marcel, Martin Ulrich, Passier Robert, Schwamborn Jens C., Stacey Glyn N., Ellinger-Ziegelbauer Heidrun, Daneshian MardasKeywords:DOI: 10.14573/altex.1710081 RISK-HUNT3R
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An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition2018 | Archives of ToxicologyTerron Andrea, Bal-Price Anna, Paini Alicia, Monnet-Tschudi Florianne, Hougaard Bennekou Susanne, Angeli Karine, Fritsche Ellen, Mantovani Alberto, Viviani Barbara, Leist Marcel, Schildknecht StefanKeywords:DOI: 10.1007/s00204-017-2133-4 RISK-HUNT3R
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Major changes of cell function and toxicant sensitivity in cultured cells undergoing mild, quasi-natural genetic drift2018 | Archives of ToxicologyGutbier Simon, May Patrick, Berthelot Sylvie, Krishna Abhimanyu, Trefzer Timo, Beaumont Maria, Behbehani Mehri, Efremova Liudmila, Delp Johannes, Gstraunthaler Gerhard, Waldmann Tanja, Leist MarcelKeywords:DOI: 10.1007/s00204-018-2326-5 RISK-HUNT3RPMID: 30298209
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Other Output
Other output published by consortium members will be available here.
Coming soon.