Publications - RISK-HUNT3R

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An Adverse Outcome Pathway Network for Chemically Induced Oxidative Stress Leading to (Non)genotoxic Carcinogenesis

2023 | Chemical Research in Toxicology

Veltman Christina H. J., Pennings Jeroen L. A., van de Water Bob, Luijten Mirjam

Keywords: Cancer · Genetics · Oxidative stress · Peptides and proteins · Toxicology

DOI: 10.1021/acs.chemrestox.2c00396 RISK-HUNT3R

PMID: 37156502
Circulating (Poly)phenol Metabolites: Neuroprotection in a 3D Cell Model of Parkinson’s Disease

2022 | Molecular nutrition & Food Research

Carecho Rafael, Figueira Inês, Terrasso Ana Paul, Godinho-Pereira Joana, de Oliveira Sequeira Catarina, Azeredo Pereira Sofia, Milenkovic Dragan, Leist Marcel, Brito Catarina, Nunes Dos Santos Cláudia

Keywords: Dopaminergic neurons · Gene expression · Neurodegeneration · Preconditioning · Transcriptomics

DOI: 10.1002/mnfr.202100959 RISK-HUNT3R

PMID: 34964254
A framework for chemical safety assessment incorporating new approach methodologies within REACH

2022 | Archives of Toxicology

Ball Nicholas, Bars Remi, Botham Philip A, Cuciureanu Andreea, Cronin Mark T D, Doe John E, Dudzina Tatsiana, Gant Timothy W, Leist Marcel, van Ravenzwaay Bennard

Keywords: Chemical risk assessment · New approach methodology · Regulatory framework · Tiered assessment · Toxicity

DOI: 10.1007/s00204-021-03215-9 RISK-HUNT3R

PMID: 35103819
Next-generation risk assessment of chemicals – Rolling out a human-centric testing strategy to drive 3R implementation: The RISK-HUNT3R project perspective

2022 | Altex

Pallocca Giorgia, Moné Martijn J., Kamp Hennicke, Luijten Mirjam, van de Water Bob, Leist Marcel

Keywords: Next-generation Risk Assessment · New Approach Methodologies · H2020 Project · RISK-HUNT3R

DOI: 10.14573/altex.2204051 RISK-HUNT3R

PMID: 35404467
Specific Attenuation of Purinergic Signaling during Bortezomib-Induced Peripheral Neuropathy In Vitro

2022 | International Journal of Molecular Sciences

Holzer Anna-Katharina, Suciu Ilinca, Karreman Christiaan, Goj Thomas, Leist Marcel

Keywords: Nociceptors · Purinergic Receptor P2X3 · Peripheral Nervous System Diseases · Bortezomib Proteasome Inhibitors

DOI: 10.3390/ijms23073734 RISK-HUNT3R

PMID: 35409095
A quantitative AOP of mitochondrial toxicity based on data from three cell lines

2022 | Toxicology in Vitro

Tebby Cleo, Wang Gao, Delp Johannes, Carta Giada, van der Stel Wanda, Leist Marcel, Jennings Paul, van de Water Bob, Bois Frederic Y

Keywords:

DOI: 10.1016/j.tiv.2022.105345 RISK-HUNT3R

PMID: 35278637
Specific attenuation of purinergic signaling during bortezomib-induced peripheral neuropathy

2022 | International Journal of Molecular Sciences

Holzer Anna-Katharina, Suciu Ilinca, Goj Thomas, Karreman Christiaan, Leist Marcel

Keywords:

DOI: 10.1101/2022.02.17.479688 RISK-HUNT3R

PMID: 35409095
Zebrafish embryo neonicotinoid developmental neurotoxicity in the FET test and behavioral assays

2022 | ALTEX

von Hellfeld Rebecca, Ovcharova Viktoriia, Bevan Samantha, Lazaridi Maria-Agapi, Bauch Caroline, Walker Paul, Hougaard Bennekou Susanne, Forsby Anna, Braunbeck Thomas

Keywords:

DOI: 10.14573/altex.2111021 RISK-HUNT3R

PMID:
Application of high-throughput transcriptomics for mechanism-based biological read-across of short-chain carboxylic acid analogues of valproic acid

2022 | ALTEX

Vrijenhoek Nanette G., Wehr Matthias, Kunnen Steven J., Wijaya Lukas S., Callegaro Giulia, Moné Martijn J., Escher Sylvia E., van de Water Bob

Keywords:

DOI: 10.14573/altex.2107261 RISK-HUNT3R

PMID:
Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation

2022 | Archives of Toxicology

van der Stel Wanda, Yang Huan, Vrijenhoek Nanette G., Schimming Johannes P., Callegaro Giulia, Carta Giada, Darici Salihanur, Delp Johannes, Forsby Anna, White Andrew, le Dévédec Sylvia, Leist Marcel, Jennings Paul, Beltman Joost B, van de Water Bob, Danen Erik

Keywords: Mitochondrial toxicity ETC complex inhibitors High-content imaging TempO-Seq DILI

DOI: 10.1007/s00204-021-03160-7 RISK-HUNT3R

PMID:
Classification of Developmental Toxicants in a Human iPSC Transcriptomics-Based Test

2022 | Chemical Research in Toxicology

Cherianidou Anna, Seidel Florian, Kappenberg Franziska, Dreser Nadine, Blum Jonathan, Blüthgen Nils, Edlund Karolina, Henry Margit, Leist Marcel, Madjar Katrin, Marchan Rosemarie, Meisig Johannes, Rahnenführer Jörg, Rotshteyn Tamara, Sachinidis Agapios, Waldmann Tanja, Hengstler Jan G.

Keywords: Antineoplastic agents · Genetics · Inhibitors · ProbesToxicity

DOI: 10.1021/acs.chemrestox.1c00392 RISK-HUNT3R

PMID: 35416653
Distinct and Dynamic Transcriptome Adaptations of iPSC-Generated Astrocytes after Cytokine Stimulation

2022 | Cells

Spreng Anna-Sophie, Brüll Markus, Leisner Heidrun, Suciu Ilinca, Leist Marcel

Keywords: Astrocytes · Cytokines · Dynamic transcriptome changes · iPSC · Inflammation

DOI: 10.3390/cells11172644 RISK-HUNT3R

PMID: 36078052
Generation of Human Nociceptor-Enriched Sensory Neurons for the Study of Pain-Related Dysfunctions

2022 | Stem Cells

Holzer Anna-Katharina, Karreman Christiaan, Furmanowsky Lara-Seline, Wohlfarth Harald, Loser Dominik, Dirks Wilhelm G., González Emilio Pardo, Leist Marcel

Keywords: TRPV cation channels · Allodynia · Nociceptors · Oxaliplatin · Peripheral nervous system diseases · Purinergic P2X3 · Receptors

DOI: 10.1093/stcltm/szac031 RISK-HUNT3R

PMID: 35689659
On the Usefulness of Animals as a Model System (Part II): Considering Benefits within Distinct Use Domains

2022 | ALTEX

Pallocca Giorgia, Leist Marcel

Keywords: BenchMarks series · Net benefit model · Performance validation · Use domain

DOI: 10.14573/altex.2207111 RISK-HUNT3R

PMID: 35871507
Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation

2022 | Archives of Toxicology

van der Stel Wanda, Yang Huan, Vrijenhoek Nanette G., Schimming Johannes P., Callegaro Giulia, Carta Giada, Darici Salihanur, Delp Johannes, Forsby Anna, White Andrew, le Dévédec Sylvia, Leist Marcel, Jennings Paul, Beltman Joost B, van de Water Bob, Danen Erik

Keywords: Mitochondrial toxicity ETC complex inhibitors High-content imaging TempO-Seq DILI

DOI: 10.1007/s00204-021-03160-7 RISK-HUNT3R

PMID:
Metabolic regulation by p53 prevents R-loop-associated genomic instability

2022 | Cell Reports

Panatta Emanuele, Butera Alessio, Mammarella Eleonora, Pitolli Consuelo, Mauriello Alessandro, Leist Marcel, Knight Richard A., Melino Gerry, Amelio Ivano

Keywords: CP: Molecular biology · Cancer · Chromosome stability · Epigenetic integrity · p53 · Tumor suppression

DOI: 10.1016/j.celrep.2022.111568 RISK-HUNT3R

PMID: 36323249
SimRFlow: An R-based workflow for automated high-throughput PBPK simulation with the Simcyp® simulator

2022 | Frontiers in Pharmacology

Khalidi Hiba, Onasanwo Anthonia, Islam Barira, Jo Heeseung, Fisher Ciarán, Aidley Rich, Gardner Iain, Bois Frederic Y.

Keywords: PBPK modelling · R · Automated data collection · High-throughput · Modular workflow · Pharmacokinetics · Simcyp simulator · Simulation

DOI: 10.3389/fphar.2022.929200 RISK-HUNT3R

PMID: 36091744
Specific Attenuation of Purinergic Signaling during Bortezomib-Induced Peripheral Neuropathy In Vitro

2022 | International Journal of Molecular Sciences

Holzer Anna-Katharina, Suciu Ilinca, Karreman Christiaan, Goj Thomas, Leist Marcel

Keywords: Bortezomib · Nociceptors · Peripheral nervous system diseases · Proteasome inhibitors · Purinergic receptor P2X3

DOI: 10.3390/ijms23073734 RISK-HUNT3R

PMID: 35409095
Studying Metabolism by NMR-Based Metabolomics

2022 | Frontiers in Molecular Biosciences

Moco Sofia

Keywords: NMR · Metabolism · Metabolite-protein interactions · Metabolomics ·qNMR · Stable isotopes

DOI: 10.3389/fmolb.2022.882487 RISK-HUNT3R

PMID: 35573745
On the usefulness of animals as a model system (part I): Overview of criteria and focus on robustness

2022 | ALTEX

Pallocca Giorgia, Rovida Costanza, Leist Marcel

Keywords: Benchmark series · Robustness · Applicability domain · Success criteria

DOI: 10.14573/altex.2203291 RISK-HUNT3R

PMID: 35413127
Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals

2022 | Chemosphere

Blum Jonathan, Masjosthusmann Stefan, Bartmann Kristina, Bendt Farina, Dolde Xenia, Dönmez Arif, Förster Nils, Holzer Anna-Katharina, Hübenthal Ulrike, Keßel Hagen Eike, Kilic Sadiye, Klose Jördis, Pahl Melanie, Stürzl Lynn-Christin, Mangas Iris, Terron Andrea, Crofton Kevin M., Scholze Martin, Mosig Axel, Leist Marcel, Fritsche Ellen

Keywords: Brain development · DNT · In vitro testing · Stem cell · Testing battery

DOI: 10.1016/j.chemosphere.2022.137035 RISK-HUNT3R

PMID: 36328314
Use of metabolic glycoengineering and pharmacological inhibitors to assess lipid and protein sialylation on cells.

2022 | Journal of Neurochemistry

Kranaster Petra, Blum Jonathan, Dold Jeremias E G A, Wittmann Valentin, Leist Marcel

Keywords: Confocal imaging · Ganglioside · Metabolic glycoengineering · Neural cell adhesion molecule · Neuron · Polysialic acid · Salic acid

DOI: 10.1111/jnc.15737 RISK-HUNT3R

PMID: 36504018
Current Status and Challenges of Human Induced Pluripotent Stem Cell-Derived Liver Models in Drug Discovery

2022 | Cells

Tricot Tine, Verfaillie Catherine M, Kumar Manoj

Keywords: Liver disease modeling · Stem cell-derived hepatocyte-like cells

DOI: 10.3390/cells11030442 RISK-HUNT3R

PMID: 35159250
High Accuracy Classification of Developmental Toxicants by In Vitro Tests of Human Neuroepithelial and Cardiomyoblast Differentiation

2022 | Cells

Seidel Florian, Cherianidou Anna, Kappenberg Franziska, Marta Miriam, Dreser Nadine, Blum Jonathan, Waldmann Tanja, Blüthgen Nils, Meisig Johannes, Madjar Katrin, Henry Margit, Rotshteyn Tamara, Scholtz-Illigens Andreas, Marchan Rosemarie, Edlund Karolina, Leist Marcel, Rahnenführer Jörg, Sachinidis Agapios, Hengstler Jan G.

Keywords: Alternative testing strategies · Developmental and reproductive toxicity · Drug screening · Gene expression · In vitro test · Induced pluripotent stem cells · Toxicogenomics · Transcriptomics

DOI: 10.3390/cells11213404 RISK-HUNT3R

PMID: 36359802
Optimization of the TeraTox Assay for Preclinical Teratogenicity Assessment

2022 | Toxicological Sciences

Jaklin Manuela, Zhang Jitao David, Schäfer Nicole, Clemann Nicole, Barrow Paul, Küng Erich, Sach-Peltason Lisa, McGinnis Claudia, Leist Marcel, Kustermann Stefan

Keywords: TeraTox · Embryoid bodies · Factor analysis · Machine learning · Molecular phenotyping · Teratogenicity

DOI: 10.1093/toxsci/kfac046 RISK-HUNT3R

PMID: 35485993
Guidance document on Good Cell and Tissue Culture Practice 2.0 (GCCP 2.0)

2022 | ALTEX

Pamies David, Leist Marcel, Coecke Sandra, Bowe Gerard, Allen David G., Gstraunthaler Gerhard, Bal-Price Anna, Pistollato Francesca, de Vries Rob B. M., Hogberg Helena T., Hartung Thomas

Keywords: Cell models · Cell culture · Good Cell and Tissue Culture Practice · GCCP

DOI: 10.14573/altex.2111011 RISK-HUNT3R

PMID: 34882777
Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation

2021 | Archives of Toxicology

van der Stel Wanda, Yang Huan, Vrijenhoek Nanette G, Schimming Johannes P, Callegaro Giulia, Carta Giada, Darici Salihanur, Delp Johannes, Forsby Anna, White Andrew, le Dévédec Sylvia, Leist Marcel, Jennings Paul, Beltman Joost B, van de Water Bob, Danen Erik H J

Keywords: Mitochondrial toxicity · ETC complex inhibitors · High-content imaging · TempO-Seq · DILI

DOI: 10.1007/s00204-021-03160-7 RISK-HUNT3R

PMID: 34642769
Synuclein Family Members Prevent Membrane Damage by Counteracting α-Synuclein Aggregation

2021 | Biomolecules

Scheibe Christian, Karreman Christiaan, Schildknecht Stefan, Leist Marcel, Hauser Karin

Keywords: Polarized ATR-FTIR · Protein–membrane Interaction · Protein–protein Interaction · Alpha-synuclein · Beta-synuclein

DOI: 10.3390/biom11081067 RISK-HUNT3R

PMID: 34439733
Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling

2021 | Archives of Toxicology

Loser Dominik, Grillberger Karin, Hinojosa Maria G., Blum Jonathan, Hauser Karin, Danker Timm, Johansson Ylva, Möller Clemens, Nicke Annette, Bennekou Suzanne H., Gardner Iain, Bauch Caroline, Walker Paul, Forsby Anna, Ecker Gerhard F, Kraushaar Udo, Leist Marcel

Keywords:

DOI: 10.1007/s00204-021-03168-z RISK-HUNT3R

PMID:
New approach methods (NAMs) supporting read-across: Two neurotoxicity AOP-based IATA case studies

2021 | ALTEX - Alternatives to animal experimentation, 38(4), pp. 615–635

van der Stel Wanda, Carta Giada, Eakins Julie, Delp Johannes, Suciu Ilinca, Forsby Anna, Cediel Ulloa Andrea Paola, Attoff Kristina, Troger Florentina, Kamp Hennicke, Gardner Iain, Zdrazil Barbara, Moné Martijn J., Ecker Gerhard F, Pastor Manuel, Gómez-Tamayo José Carlos, White Andrew, Danen Erik, Leist Marcel, Walker Paul, Jennings Paul, Bennekou Suzanne H., van de Water Bob

Keywords: in vitro mitochondrial toxicity neurotoxicity PBK-modelling uncertainty analysis

DOI: https://doi.org/10.14573/altex.2103051 RISK-HUNT3R

PMID:
The in vitro assessment of the toxicity of volatile, oxidisable, redox-cycling compounds: phenols as an example

2021 | Archives of Toxicology volume 95, pages2109–2121 (2021)

Tolosa Laia, Martinez-Sena Teresa, Schimming Johannes P., Moro Erika, Escher Sylvia E., ter Braak Bas, van de Water Bob, Miranda M. A., van Vugt-Lussenburg Barbara M A, Castell Jose V

Keywords: Toxicity of phenols; Redox-cycling phenols; In vitro toxicity; Hepatotoxicity; Cross-contamination of culture wells; Plastic seals; High-content imaging; HepG2 BAC-GFP SRXN1 assay; Nrf2 CALUX reporter gene assay; Cytotox CALUX reporter gene assay

DOI: https://doi.org/10.1007/s00204-021-03036-w RISK-HUNT3R

PMID:
Generation and characterization of iPSC-derived renal proximal tubule-like cells with extended stability

2021 | Scientific Reports volume 11, Article number: 11575 (2021)

Chandrasekaran Vidya, Carta Giada, da Costa Pereira Daniel, Gupta Rajinder, Murphy Cormac, Feifel Elisabeth, Kern Georg, Lechner Judith, Cavallo Anna Lina, Gupta Shailesh, Caiment Florian, Kleinjans Jos C S, Gstraunthaler Gerhard, Jennings Paul, Wilmes Anja

Keywords: Cell biology; Stem cells

DOI: https://doi.org/10.1038/s41598-021-89550-4 RISK-HUNT3R

PMID:
Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery

2021 | Cell Biology and Toxicology (2021)

Klose Jördis, Pahl Melanie, Bartmann Kristina, Bendt Farina, Blum Jonathan, Dolde Xenia, Förster Nils, Holzer Anna-Katharina, Hübenthal Ulrike, Keßel Hagen Eike, Koch Katharina, Masjosthusmann Stefan, Schneider Sabine, Stürzl Lynn-Christin, Woeste Selina, Rossi Andrea, Covaci Adrian, Behl Mamta, Leist Marcel, Tigges Julia, Fritsche Ellen

Keywords: Developmental neurotoxicity; Flame retardants; Human cell–based testing battery; 3D in vitro model; New approach methodologies; Hazard assessment

DOI: https://doi.org/10.1007/s10565-021-09603-2 RISK-HUNT3R

PMID:
Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes

2021 | Cell Biology and Toxicology (2021)

Wijaya Lukas S., Rau Carina, Braun Theresa S., Marangoz Serif, Spegg Vincent, Vlasveld Matthijs, Albrecht Wiebke, Brecklinghaus Tim, Kamp Hennicke, Beltman Joost B, Hengstler Jan G., van de Water Bob, Leist Marcel, Schildknecht Stefan

Keywords: Nitrofurantoin; Hepatocytes; Nrf2; Glutathione; Cytochrome P450 reductase

DOI: https://doi.org/10.1007/s10565-021-09610-3 RISK-HUNT3R

PMID:
Integration of temporal single cell cellular stress response activity with logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver injury

2021 | Biochemical Pharmacology

Wijaya Lukas S., Trairatphisan Panuwat, Gabor Attila, Niemeijer Marije, Keet Jason, Alcalà Morera Ariadna, Snijders Kirsten E., Wink Steven, Yang Huan, Schildknecht Stefan, Stevens James L., Bouwman Peter, Kamp Hennicke, Hengstler Jan G., Beltman Joost B, Leist Marcel, le Dévédec Sylvia, Saez-Rodriguez Julio, van de Water Bob

Keywords: GFP-reporter; Logic-ODE; Stress response pathway; Drug-induced liver injury (DILI)

DOI: https://doi.org/10.1016/j.bcp.2021.114591 RISK-HUNT3R

PMID:
A human stem cell-derived test system for agents modifying neuronal N-methyl-D-aspartate-type glutamate receptor Ca2+-signalling

2021 | Archives of Toxicology volume 95, pages 1703–1722 (2021)

Klima Stefanie, Brüll Markus, Spreng Anna-Sophie, Suciu Ilinca, Falt Tjalda, Schwamborn Jens C., Waldmann Tanja, Karreman Christiaan, Leist Marcel

Keywords: Ketamine; MEA; Phencyclidine; Dextromethorphan; Domoic acid; Neurotoxicity; Ibotenic acid

DOI: https://doi.org/10.1007/s00204-021-03024-0 RISK-HUNT3R

PMID:
Physiologically Relevant Estrogen Receptor Alpha Pathway Reporters for Single-Cell Imaging-Based Carcinogenic Hazard Assessment of Estrogenic Compounds

2021 | Toxicological Sciences, Volume 181, Issue 2, June 2021, Pages 187–198

Duijndam Britt, Goudriaan Annabel, van den Hoorn Tineke, van der Stel Wanda, le Dévédec Sylvia, Bouwman Peter, van der Laan Jan Willem, van de Water Bob

Keywords: Estrogen receptor alpha, fluorescent reporters, live-cell imaging, single cell

DOI: https://doi.org/10.1093/toxsci/kfab037 RISK-HUNT3R

PMID:
Systematic transcriptome-based comparison of cellular adaptive stress response activation networks in hepatic stem cell-derived progeny and primary human hepatocytes

2021 | Toxicology in Vitro

ter Braak Bas, Niemeijer Marije, Boon Ruben, Parmentier Céline, Baze Audrey, Richert Lysiane, Huppelschoten Suzanna, Wink Steven, Verfaillie Catherine M, van de Water Bob

Keywords:

DOI: 10.1016/j.tiv.2021.105107 RISK-HUNT3R

PMID:
Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons

2021 | Archives of Toxicology volume 95, pages 2081–2107 (2021)

Loser Dominik, Hinojosa Maria G., Blum Jonathan, Schaefer Jasmin, Brüll Markus, Johansson Ylva, Suciu Ilinca, Grillberger Karin, Danker Timm, Möller Clemens, Gardner Iain, Ecker Gerhard F, Bennekou Suzanne H., Forsby Anna, Kraushaar Udo, Leist Marcel

Keywords: Live-cell calcium imaging; Neurotoxicity; Nicotine; Desensitization; Molecular docking

DOI: https://doi.org/10.1007/s00204-021-03031-1 RISK-HUNT3R

PMID:
Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling

2021 | Archives of Toxicology

Loser Dominik, Grillberger Karin, Hinojosa Maria G., Blum Jonathan, Hauser Karin, Danker Timm, Johansson Ylva, Möller Clemens, Nicke Annette, Bennekou Suzanne H., Gardner Iain, Bauch Caroline, Walker Paul, Forsby Anna, Ecker Gerhard F, Kraushaar Udo, Leist Marcel

Keywords: Developmental neurotoxicity; Live-cell calcium imaging; Molecular docking; Nicotine; Oocyte recording; Pesticide metabolism.

DOI: 10.1007/s00204-021-03168-z RISK-HUNT3R

PMID: 34628512
Profiling of Human Neural Crest Chemoattractant Activity as a Replacement of Fetal Bovine Serum for In Vitro Chemotaxis Assays

2021 | International Journal of Molecular Sciences

Dolde Xenia, Karreman Christiaan, Wiechers Marianne, Schildknecht Stefan, Leist Marcel

Keywords: Cell migration · Chemotaxis · Fetal bovine serum · Human platelet lysate · Neural crest cells

DOI: 10.3390/ijms221810079 RISK-HUNT3R

PMID: 34576243
Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment

2020 | Environment International

Drakvik Paula E, Altenburger Rolf, Aoki Yasunobu, Backhaus Thomas, Bahadori Tina, Barouki Robert, Brack Werner, Cronin Mark T. D., Demeneix Barbara, Bennekou Suzanne H., van Klaveren Jacob, Kneuer Carsten, Kolossa-Gehring Marike, Lebret Erik, Posthuma Leo, Reiber Lena, Rider Cynthia, Ruegg Joelle, Testa Giuseppe, van der Burg Bart, van der Voet Hilko, Warhurst A. Michael, van de Water Bob, Yamazaki Kunihiko, Öberg Mattias, Bergman Åke

Keywords:

DOI: 10.1016/j.envint.2019.105267 RISK-HUNT3R

PMID:
Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals

2020 | Archives of Toxicology

van der Stel Wanda, Carta Giada, Eakins Julie, Darici Salihanur, Delp Johannes, Forsby Anna, Hougaard Bennekou Susanne, Gardner Iain, Leist Marcel, Danen Erik H J, Walker Paul, van de Water Bob, Jennings Paul

Keywords:

DOI: 10.1007/s00204-020-02792-5 RISK-HUNT3R

PMID: 32607615
Determination of benchmark concentrations and their statistical uncertainty for cytotoxicity test data and functional in vitro assays

2020 | Altex

Krebs Alice, Nyffeler Johanna, Karreman Christiaan, Schmidt Béla Z., Mellert Werner, Pallocca Giorgia, Pastor Manuel, Rahnenführer Jörg, Leist Marcel

Keywords:

DOI: https://doi.org/10.14573/altex.1912021 RISK-HUNT3R

PMID:
Harnessing the power of novel animal-free test methods for the development of COVID-19 drugs and vaccines

2020 | Archives of Toxicology

Busquet Francois, Hartung Thomas, Pallocca Giorgia, Rovida Costanza, Leist Marcel

Keywords:

DOI: 10.1007/s00204-020-02787-2 RISK-HUNT3R

PMID: 32447523
The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods

2020 | Archives of Toxicology

Krebs Alice, van Vugt-Lussenburg Barbara M A, Waldmann Tanja, Albrecht Wiebke, Boei Jan J, ter Braak Bas, Brajnik Maja, Braunbeck Thomas, Brecklinghaus Tim, Exner Thomas, Fisher Ciarán, Fluri David A, Forsby Anna, Hengstler Jan G., Holzer Anna-Katharina, Janstova Zofia, Jennings Paul, Kisitu Jaffar, Kobolák Julianna, Kumar Manoj, Limonciel Alice, Lundqvist Jessica, Mihalik Balázs, Moritz Wolfgang, Pallocca Giorgia, Cediel Ulloa Andrea Paola, Pastor Manuel, Rovida Costanza, Sarkans Ugis, Schimming Johannes P, Schmidt Béla Z., Stoeber Regina, Strassfeld Tobias, van de Water Bob, Wilmes Anja, van der Burg Bart, Verfaillie Catherine M, von Hellfeld Rebecca, Vrieling Harry, Vrijenhoek Nanette G, Leist Marcel

Keywords:

DOI: 10.1007/s00204-020-02802-6 RISK-HUNT3R

PMID: 32632539
Design and evaluation of bi-functional iron chelators for protection of dopaminergic neurons from toxicants

2020 | Archives of Toxicology

Gutbier Simon, Kyriakou Sotiris, Schildknecht Stefan, Ückert Anna-Katharina, Brüll Markus, Lewis Frank, Dickens David, Pearson Liam, Elson Joanna L., Michel Sylvia, Hubscher-Bruder Véronique, Brandel Jeremy, Tetard David, Leist Marcel, Pienaar Ilse S.

Keywords:

DOI: 10.1007/s00204-020-02826-y RISK-HUNT3R

PMID: 32607613
Incorporation of stem cell-derived astrocytes into neuronal organoids to allow neuro-glial interactions in toxicological studies

2020 | Altex

Brüll Markus, Spreng Anna-Sophie, Gutbier Simon, Loser Dominik, Krebs Alice, Reich Marvin, Kraushaar Udo, Britschgi Markus, Patsch Christoph, Leist Marcel

Keywords:

DOI: https://doi.org/10.14573/altex.1911111 RISK-HUNT3R

PMID: 32150624
ATF6 Is a Critical Determinant of CHOP Dynamics during the Unfolded Protein Response

2020 | iScience

Yang Huan, Niemeijer Marije, van de Water Bob, Beltman Joost B

Keywords:

DOI: 10.1016/j.isci.2020.100860 RISK-HUNT3R

PMID: 32058971
Towards grouping concepts based on new approach methodologies in chemical hazard assessment: the read-across approach of the EU-ToxRisk project

2019 | Archives of Toxicology

Escher Sylvia E., Kamp Hennicke, Bennekou Suzanne H., Bitsch Annette, Fisher Ciarán, Graepel Rabea, Hengstler Jan G., Herzler Matthias, Knight Derek, Leist Marcel, Norinder Ulf, Ouedraogo Gladys, Pastor Manuel, Stuard Sharon B., White Andrew, Zdrazil Barbara, van de Water Bob, Kroese E. Dinant

Keywords:

DOI: 10.1007/s00204-019-02591-7 RISK-HUNT3R

PMID:
Optimizing drug discovery by investigative toxicology: Current and future trends

2019 | ALTEX - Alternatives to animal experimentation

Beilmann Mario, Boonen Harrie, Czich Andreas, Dear Gordon, Hewitt Philip, Mow Tomas, Newham Peter, Oinonen Teija, Pognan François, Roth Adrian, Valentin Jean-Pierre, Van Goethem Freddy, Weaver Richard, Birk Barbara, Boyer Scott, Caloni Francesca, Chen Alice, Corvi Raffaella, Cronin Mark T. D., Daneshian Mardas, Ewart Lorna, Fitzgerald Rex, Hamilton Geraldine, Hartung Thomas, Kangas Joshua, Kramer Nynke I., Leist Marcel, Marx Uwe, Polak Sebastian, Rovida Costanza, Testai Emanuela, van de Water Bob, Vulto Paul, Steger-Hartmann Thomas

Keywords: AOP microphysiological systems drug safety predictive tools risk assessment

DOI: 10.14573/altex.1808181 RISK-HUNT3R

PMID:
A systematic analysis of Nrf2 pathway activation dynamics during repeated xenobiotic exposure

2019 | Archives of Toxicology

Bischoff Luc J. M., Kuijper Isoude A, Schimming Johannes P, Wolters Liesanne, ter Braak Bas, Langenberg Jan P., Noort Daan, Beltman Joost B, van de Water Bob

Keywords: Nrf2; Srxn1; Repeated exposure; HepG2; Oxidative stress; Soft electrophiles

DOI: https://doi.org/10.1007/s00204-018-2353-2 RISK-HUNT3R

PMID:
Current EU research activities on combined exposure to multiple chemicals

2019 | Environment International

Bopp Stephanie K, Barouki Robert, Brack Werner, Dalla Costa Silvia, Dorne Jean Lou, Drakvik Paula E, Faust Michael, Karjalainen Tuomo K, Kephalopoulos Stylianos, van Klaveren Jacob, Kolossa-Gehring Marike, Kortenkamp Andreas, Lebret Erik, Lettieri Teresa, Nørager Sofie, Ruegg Joelle, Tarazona Jose V, Trier Xenia, van de Water Bob, van Gils Jos, Bergman Åke

Keywords:

DOI: 10.1016/j.envint.2018.07.037 RISK-HUNT3R

PMID:
Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury

2019 | Archives of Toxicology

Copple Ian M., den Hollander Wouter, Callegaro Giulia, Mutter Fiona E., Maggs James L., Schofield Amy L., Rainbow Lucille, Fang Yongxiang, Sutherland Jeffrey J., Ellis Ewa C., Ingelman-Sundberg Magnus, Fenwick Stephen W., Goldring Christopher E., van de Water Bob, Stevens James L., Park B. Kevin

Keywords:

DOI: 10.1007/s00204-018-2354-1 RISK-HUNT3R

PMID:
Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes

2019 | Archives of Toxicology volume 92, pages 3517–3533 (2018)

Grinberg Marianna, Stoeber Regina, Albrecht Wiebke, Edlund Karolina, Schug Markus, Godoy Patricio, Cadenas Cristina, Marchan Rosemarie, Lampen Alfonso, Braeuning Albert, Buhrke Thorsten, Leist Marcel, Oberemm Axel, Hellwig Birte, Kamp Hennicke, Gardner Iain, Escher Sylvia E., Taboureau Olivier, Aguayo-Orozco Alejandro, Sachinidis Agapios, Ellinger-Ziegelbauer Heidrun, Rahnenführer Jörg, Hengstler Jan G.

Keywords: Rat liver; Cultivated hepatocytes; Hepatotoxicity; Ranking analysis; Batch effect correction; Bioinformatics

DOI: 10.1007/s00204-018-2352-3 RISK-HUNT3R

PMID:
Application of three approaches for quantitative AOP development to renal toxicity

2019 | Computational Toxicology

Zgheib Elias, Wang Gao, Limonciel Alice, Aladjov Hristo, Yang Huan, Tebby Cleo, Gayraud Ghislaine, Jennings Paul, Sachana Magdalini, Beltman Joost B, Bois Frederic Y

Keywords:

DOI: 10.1016/j.comtox.2019.02.001 RISK-HUNT3R

PMID:
Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations

2019 | Archives of Toxicology

Albrecht Wiebke, Kappenberg Franziska, Brecklinghaus Tim, Stoeber Regina, Marchan Rosemarie, Zhang Mian, Ebbert Kristina, Grinberg Marianna, Leist Marcel, Moritz Wolfgang, Cadenas Cristina, Ghallab Ahmed, Reinders Jörg, Vartak Nachiket, van Thriel Christoph, Golka Klaus, Tolosa Laia, Castell Jose V, Damm Georg, Seehofer Daniel, Lampen Alfonso, Braeuning Albert, Buhrke Thorsten, Behr Anne-Cathrin, Oberemm Axel, Gu Xiaolong, Kittana Naim, van de Water Bob, Kreiling Reinhard, Fayyaz Susann, van Aerts Leon, Smedsrød Bård, Ellinger-Ziegelbauer Heidrun, Steger-Hartmann Thomas, Gundert-Remy Ursula, Zeigerer Anja, Ullrich Anett, Runge Dieter, Lee Serene M. L., Schiergens Tobias S., Kuepfer Lars, Aguayo-Orozco Alejandro, Sachinidis Agapios, Edlund Karolina, Gardner Iain, Rahnenführer Jörg, Hengstler Jan G.

Keywords:

DOI: 10.1007/s00204-019-02492-9 RISK-HUNT3R

PMID:
Development of a neurotoxicity assay that is tuned to detect mitochondrial toxicants

2019 | Archives of Toxicology

Delp Johannes, Funke Melina, Rudolf Franziska, Cediel Andrea, Hougaard Bennekou Susanne, van der Stel Wanda, Carta Giada, Jennings Paul, Toma Cosimo, Gardner Iain, van de Water Bob, Forsby Anna, Leist Marcel

Keywords:

DOI: 10.1007/s00204-019-02473-y RISK-HUNT3R

PMID:
Paradigm shift in safety assessment using new approach methods: The EU-ToxRisk strategy

2019 | Current Opinion in Toxicology Volume 15, June 2019, Pages 33-39

Graepel Rabea, ter Braak Bas, Escher Sylvia E., Fisher Ciarán, Gardner Iain, Kamp Hennicke, Kroese E. Dinant, Leist Marcel, Moné Martijn J., Pastor Manuel, van de Water Bob

Keywords:

DOI: 10.1016/j.cotox.2019.03.005 RISK-HUNT3R

PMID:
Chemical concentrations in cell culture compartments (C5) – concentration definitions

2019 | ALTEX

Kisitu Jaffar, Hougaard Bennekou Susanne, Leist Marcel

Keywords:

DOI: 10.14573/altex.1901031 RISK-HUNT3R

PMID:
System Microscopy of Stress Response Pathways in Cholestasis Research

2019 | Methods in Molecular Biology

Schimming Johannes P., ter Braak Bas, Niemeijer Marije, Wink Steven, van de Water Bob

Keywords:

DOI: 10.1007/978-1-4939-9420-5_13 RISK-HUNT3R

PMID:
SUIKER: Quantification of antigens in cell organelles, neurites and cellular sub-structures by imaging

2019 | ALTEX

Karreman Christiaan, Kranaster Petra, Leist Marcel

Keywords:

DOI: 10.14573/altex.1906251 RISK-HUNT3R

PMID:
Finding synergies for the 3Rs – Repeated Dose Toxicity testing: Report from an EPAA Partners' Forum

2019 | Regulatory Toxicology and Pharmacology Volume 108, November 2019, 104470

Laroche Charles, Annys Erwin, Bender Hans, Botelho Danielle, Botham Philip, Brendler-Schwaab Susanne, Clayton Rick, Covaro Marco, Dal Negro Gianni, Delannois Frédérique, Dent Matt, Desaintes Christian, Desprez Bertrand, Dhalluin Stephane, Hartmann Andreas, Hoffmann-Doerr Simone, Hubesch Bruno, Irizar Amaia, Manou Irene, Müller Boris P., Nadzialek Stephanie, Prieto Pilar, Rasenberg Mike, Roggeband Rob, Rowan Tim G., Schutte Katrin, van de Water Bob, Westmoreland Carl, Whelan Maurice, Wilschut Annette, Zvonimir Zvonar, Cronin Mark T. D.

Keywords:

DOI: 10.1016/j.yrtph.2019.104470 RISK-HUNT3R

PMID:
High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability

2019 | Archives of Toxicology volume 93, pages 2895–2911 (2019)

Hiemstra Steven, Ramaiahgari Sreenivasa C., Wink Steven, Callegaro Giulia, Meerman John, Jennen Danyel, van den Nieuwendijk Karen, Dankers Anita, Snoeys Jan, de Bont Hans, Price Leo, van de Water Bob

Keywords:

DOI: 10.1007/s00204-019-02552-0 RISK-HUNT3R

PMID:
Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data

2019 | ALTEX

Krebs Alice, Waldmann Tanja, Wilks Martin F, van Vugt-Lussenburg Barbara M A, van der Burg Bart, Terron Andrea, Steger-Hartmann Thomas, Ruegg Joelle, Rovida Costanza, Pedersen Emma, Pallocca Giorgia, Luijten Mirjam, Leite Sofia B., Kustermann Stefan, Kamp Hennicke, Hoeng Julia, Hewitt Philip, Herzler Matthias, Hengstler Jan G., Heinonen Tuula, Hartung Thomas, Hardy Barry, Gantner Florian, Fritsche Ellen, Fant Kristina, Ezendam Janine, Exner Thomas, Dunkern Torsten, Dietrich Daniel R., Coecke Sandra, Busquet Francois, Braeuning Albert, Bondarenko Olesja, Bennekou Suzanne H., Beilmann Mario, Leist Marcel

Keywords:

DOI: 10.14573/altex.1909271 RISK-HUNT3R

PMID:
Development of a neural rosette formation assay (RoFA) to identify neurodevelopmental toxicants and to characterize their transcriptome disturbances

2019 | Archives of Toxicology

Dreser Nadine, Madjar Katrin, Holzer Anna-Katharina, Kapitza Marion, Scholz Christopher, Kranaster Petra, Gutbier Simon, Klima Stefanie, Kolb David, Dietz Christian, Trefzer Timo, Meisig Johannes, van Thriel Christoph, Henry Margit, Berthold Michael R., Blüthgen Nils, Sachinidis Agapios, Rahnenführer Jörg, Hengstler Jan G., Waldmann Tanja, Leist Marcel

Keywords:

DOI: 10.1007/s00204-019-02612-5 RISK-HUNT3R

PMID:
Time and space-resolved quantification of plasma membrane sialylation for measurements of cell function and neurotoxicity

2019 | Archives of Toxicology

Kranaster Petra, Karreman Christiaan, Dold Jeremias E G A, Krebs Alice, Funke Melina, Holzer Anna-Katharina, Klima Stefanie, Nyffeler Johanna, Helfrich Stefan, Wittmann Valentin, Leist Marcel

Keywords:

DOI: 10.1007/s00204-019-02642-z RISK-HUNT3R

PMID: 31828357
Prevention of neuronal apoptosis by astrocytes through thiol-mediated stress response modulation and accelerated recovery from proteotoxic stress

2018 | Cell Death & Differentiation volume 25, pages 2101–2117 (2018)

Gutbier Simon, Spreng Anna-Sophie, Delp Johannes, Schildknecht Stefan, Karreman Christiaan, Suciu Ilinca, Brunner Thomas, Groettrup Marcus, Leist Marcel

Keywords:

DOI: 10.1038/s41418-018-0229-x RISK-HUNT3R

PMID:
Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds

2018 | npj Systems Biology and Applications

Oppelt Angela, Kaschek Daniel, Huppelschoten Suzanna, Sison-Young Rowena, Zhang Fang, Buck-Wiese Marie, Herrmann Franziska, Malkusch Sebastian, Krüger Carmen L., Meub Mara, Merkt Benjamin, Zimmermann Lea, Schofield Amy L., Jones Robert P., Malik Hassan, Schilling Marcel, Heilemann Mike, van de Water Bob, Goldring Christopher E., Park B. Kevin, Timmer Jens, Klingmüller Ursula

Keywords:

DOI: 10.1038/s41540-018-0058-z RISK-HUNT3R

PMID: 29900006
Advanced Good Cell Culture Practice for human primary, stem cell-derived and organoid models as well as microphysiological systems

2018 | ALTEX

Pamies David, Bal-Price Anna, Chesne Christophe, Coecke Sandra, Dinnyés András, Eskes Chantra, Grillari Regina, Gstraunthaler Gerhard, Hartung Thomas, Jennings Paul, Leist Marcel, Martin Ulrich, Passier Robert, Schwamborn Jens C., Stacey Glyn N., Ellinger-Ziegelbauer Heidrun, Daneshian Mardas

Keywords:

DOI: 10.14573/altex.1710081 RISK-HUNT3R

PMID:
An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition

2018 | Archives of Toxicology

Terron Andrea, Bal-Price Anna, Paini Alicia, Monnet-Tschudi Florianne, Hougaard Bennekou Susanne, Angeli Karine, Fritsche Ellen, Mantovani Alberto, Viviani Barbara, Leist Marcel, Schildknecht Stefan

Keywords:

DOI: 10.1007/s00204-017-2133-4 RISK-HUNT3R

PMID:
Major changes of cell function and toxicant sensitivity in cultured cells undergoing mild, quasi-natural genetic drift

2018 | Archives of Toxicology

Gutbier Simon, May Patrick, Berthelot Sylvie, Krishna Abhimanyu, Trefzer Timo, Beaumont Maria, Behbehani Mehri, Efremova Liudmila, Delp Johannes, Gstraunthaler Gerhard, Waldmann Tanja, Leist Marcel

Keywords:

DOI: 10.1007/s00204-018-2326-5 RISK-HUNT3R

PMID: 30298209

fas|fa-parachute-box|

Other Output

Other output published by consortium members will be available here.

Coming soon.