fas|fa-globe-africa|

RISK-HUNT3R consortium

fas|fa-users|

Scientific & Regulatory Advisory Board (SRAB)

fas|fa-cogs|

Collaborations

fas|fa-globe-africa|

RISK-HUNT3R consortium

RISK-HUNT3R consortium

RISK-HUNT3R gathers a total of 37 European partners from 11 countries forming a multidisciplinary panel of experts comprising academic and institutional reseachers, regulators from national and international authorities, as well as safety scientists from various industry sectors (SMEs and large industry).
Partners combine state-of-the-art expertise in human toxicology, molecular cell biology, tissue engineering, omics approaches, quantitative systems biology, human exposure, chemoinformatics, biokinetics, PBK modelling, biostatistics, and risk assessment. The scientific excellence is complemented by experts in management, dissemination, and training, making sure that the project runs smoothly and achieves maximum impact.

RISK HUNT3R - Partner

RISK-HUNT3R Partners

RISK HUNT3R - Third Linked Partner

RISK-HUNT3R Linked Third Party

Title Address Description
UNIVERSITEIT LEIDEN (UL)
Rapenburg 70, 2311 EZ Leiden, Netherlands
RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU
Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, Netherlands
FRAUNHOFER GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG EV
Nikolai-Fuchs-Straße 1, 30625 Hannover, Germany
CERTARA UK LIMITED
Level 2, Acero, 1 Concourse Way, Sheffield City Centre, Sheffield S1 2BJ, UK
UNIVERSITÄT KONSTANZ
Universitätsstraße 10, 78464 Konstanz, Germany
LIVERPOOL JOHN MOORES UNIVERSITY
Roscoe Court, 2 Rodney St, Liverpool L1 2UA, UK
EDELWEISS CONNECT GMBH
Hochbergerstrasse 60C, 4057 Basel, Switzerland
DANMARKS TEKNISKE UNIVERSITET
Anker Engelunds Vej 1 Bygning 101A, 2800 Kgs. Lyngby, Denmark
STEINBEIS GMBH & CO. KG FUER TECHNOLOGIETRANSFER
Willi-Bleicher-Straße 19, 70174 Stuttgart, Germany
ARTTIC
37 Rue Bergère, 75009 Paris, France
BASF SE
Carl-Bosch-Straße 38, 67063 Ludwigshafen am Rhein, Germany
UPPSALA UNIVERSITET
von Kraemers allé 4, 751, 752 37 Uppsala, Sweden
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
101 Rue de Tolbiac, 75013 Paris, France
EUROPEAN MOLECULAR BIOLOGY LABORATORY / European Bioinformatics Institute
Wellcome Trust Genome Campus, Hinxton, Saffron Walden CB10 1SA, UK
BUNDESINSTITUT FUER RISIKOBEWERTUNG
Max-Dohrn-Straße 8-10, 10589 Berlin, Germany
RISE RESEARCH INSTITUTES OF SWEDEN AB
Forskargatan 20j, 151 36 Södertälje, Sweden
UNILEVER U.K. CENTRAL RESOURCES LIMITED
Colworth Laboratory, Colworth House, Sharnbrook, Bedford MK44 1LQ, UK
KAROLINSKA INSTITUTET
Nobels väg 5, 171 65 Solna, Sweden
KATHOLIEKE UNIVERSITEIT LEUVEN
Waaistraat 6, 3000 Leuven, Belgium
LATVIJAS ORGANISKAS SINTEZES INSTITUTS
Aizkraukles iela 21, Vidzemes priekšpilsēta, Rīga, LV-1006, Latvia
KOBENHAVNS UNIVERSITET
Nørregade 10, 1165 København, Denmark
LUNDS UNIVERSITET
Paradisgatan 5, 223 50 Lund, Sweden
UNIVERSIDAD POMPEU FABRA
Edif. Mercè, Plaça de la Mercè, 10-12, 08002 Barcelona, Spain
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Heidelberglaan 100, 3584 CX Utrecht, Netherlands
UNIVERSITAT WIEN
Universitätsring 1, 1010 Wien, Austria
STICHTING VU
Hoofdgebouw, De Boelelaan 1105, 1081 HV Amsterdam, Netherlands
BioDetection Systems B.V.
MATRIX Innovation Center, Science Park 406, 1098 XH Amsterdam, Netherlands
SIGNATOPE GMBH
Markwiesenstraße 55, 72770 Reutlingen, Germany
TISSUSE GMBH
Oudenarder Str. 16, 13347 Berlin, Germany
BIOCLAVIS LIMITED
1345 Govan Rd, Glasgow G51 4TF, UK
NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETEN- SCHAPPELIJK ONDERZOEK
Anna van Buerenplein 1, 2595 DE Den Haag, Netherlands
COSMETICS EUROPE - THE PERSONAL CARE ASSOCIATION
Herrmann-Debrouxlaan 40, 1160 Oudergem, Belgium
L'OREAL SA
14 Rue Royale, 75008 Paris, France
BAYER SAS
355 Rue Fedor Dostoïevski, 06560 Valbonne, France
CHARLES RIVER LABORATORIES DEN BOSCH BV
Hambakenwetering 7, 5231 DD 's-Hertogenbosch, Netherlands
INDUSTRIA DE DISENO TEXTIL SA
15143 Arteixo, A Coruña, Spain
MEDBIOINFORMATICS SOLUTIONS SL
Carrer dels Almogàvers, 165, 08018 Barcelona, Spain
BASF Metabolome Solutions GmbH
Tegeler Weg 33, 10589 Berlin, Germany
Prof. Dr. Bob VAN DE WATER

Prof. Dr. Bob VAN DE WATER

Chair of the Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR)

PROJECT COORDINATOR

Dr. Mirjam LUIJTEN

Dr. Mirjam LUIJTEN

Senior research toxicologist

Dr. Annette BITSCH

Dr. Annette BITSCH

Biologist/toxicologist, Head of the division Chemical Safety and Toxicology

Dr. Ciarán FISHER

Dr. Ciarán FISHER

Principal Scientist QSTS

Prof. Dr. Marcel LEIST

Prof. Dr. Marcel LEIST

Head of the department of in vitro toxicology and biomedicine

Prof. Dr. Mark CRONIN

Prof. Dr. Mark CRONIN

Professor of Predictive Toxicology

Dr. Barry HARDY

Dr. Barry HARDY

Managing Director

Dr. Susanne HOUGAARD BENNEKOU

Dr. Susanne HOUGAARD BENNEKOU

Senior Advisor at FOOD/DTU; Regulatory toxicologist

Dr. Giorgia PALLOCCA

Dr. Giorgia PALLOCCA

Deputy Director of Steinbeis CAAT-Europe

Annette RINGWALD

Annette RINGWALD

Senior Consultant, Deputy Director

Dr. Franziska ZICKGRAF

Dr. Franziska ZICKGRAF

Experimental Toxicology and Ecology

Prof. Dr. Per ARTURSSON

Prof. Dr. Per ARTURSSON

Professor and head of the Drug Delivery Group

Prof. Dr. Olivier TABOUREAU

Prof. Dr. Olivier TABOUREAU

Professor

Dr. Ugis SARKANS

Dr. Ugis SARKANS

Team Leader - Functional Genomics Development

Dr. Michael OELGESCHLÄGER

Dr. Michael OELGESCHLÄGER

Head of Unit “Strategies for Toxicological Assessments”, Department Experimental Toxicology and ZEBET

Prof. Dr. Ian COTGREAVE

Prof. Dr. Ian COTGREAVE

Senior Scientist and Strategist at RISE (Chemical and Pharmaceutical Safety); Professor of Toxicology (Karolinska Institute)

Dr. Andrew WHITE

Dr. Andrew WHITE

Science Leader in Computational Toxicology, Safety and Environment Assurance Centre (SEAC)

Prof. Dr. Roland GRAFSTRÖM

Prof. Dr. Roland GRAFSTRÖM

Professor, Institute of Environmental Medicine (IMM)

Prof. Dr. Catherine VERFAILLIE

Prof. Dr. Catherine VERFAILLIE

Professor of Medicine, Director of the Stem Cell Institute Leuven

Dr. pharm. Edgars LIEPIŅŠ

Dr. pharm. Edgars LIEPIŅŠ

Leading Researcher

Prof. Dr. Søren BRUNAK

Prof. Dr. Søren BRUNAK

Research Program Director, Professor

Dr. Ullrika SAHLIN

Dr. Ullrika SAHLIN

Associate Professor

Dr. Manuel PASTOR

Dr. Manuel PASTOR

Head of the Pharmaco Informatics Group of GRIB

Prof. Dr. Roel VERMEULEN

Prof. Dr. Roel VERMEULEN

Professor Environmental Epidemiology and Exposome Science

Prof. Dr. Gerhard ECKER

Prof. Dr. Gerhard ECKER

Head of Pharmacoinformatics Research Group, Dean of Faculty of Life Sciences

Prof. Dr. Paul JENNINGS

Prof. Dr. Paul JENNINGS

Head of Molecular and Computational Toxicology

Dr. Bart VAN DER BURG

Dr. Bart VAN DER BURG

Director of Innovation

Dr. Oliver PÖTZ

Dr. Oliver PÖTZ

CEO/CSO

Dr.-Ing. Eva DEHNE

Dr.-Ing. Eva DEHNE

Research Coordinator

Dr. Harper VANSTEENHOUSE

Dr. Harper VANSTEENHOUSE

President

Dr. Dinant KROESE

Dr. Dinant KROESE

Senior Research Scientist

Dr. Rob TAALMAN

Dr. Rob TAALMAN

Science & Research Director

Dr. Gladys OUEDRAOGO

Dr. Gladys OUEDRAOGO

Scientific Officer

Dr. Remi BARS

Dr. Remi BARS

Scientific Director Toxicology

Dr. Walter WESTERINK

Dr. Walter WESTERINK

Section Head Flexible Innovation Team

Héctor ALONSO

Héctor ALONSO

Sustainability-Science, Technology and Innovation Manager

Dr. Laura FURLONG

Dr. Laura FURLONG

CO-founder and Chief Scientific Officer

Linked Third Party

Prof. Dr. Hennicke KAMP

Prof. Dr. Hennicke KAMP

Managing Director, Toxicologist (ERT)

BASF Metabolome Solutions GmbH

fas|fa-users|

Scientific & Regulatory Advisory Board (SRAB)

Scientific & Regulatory Advisory Board (SRAB)

The RISK-HUNT3R project works in close collaboration with an independent international Scientific & Regulatory Advisory Board (SRAB) composed of a representative panel of independent experts from regulatory agencies and industry. The SRAB provides advice on relevant issues from a scientific, regulatory, industrial and ethical perspective. As such, their expertise and feedback will be of great value to ensure relevance of the various project case studies, but also on a higher level regarding. for example, scrutiny of overall work and results quality, and warranting scientific and technological state of the art.

The members of the SRAB are the following:

  • Thomas STEGER-HARTMANN, Bayer AG, Research & Development, Pharmaceuticals
  • Matthias HERZLER, The German Federal Institute for Risk Assessment (BfR)
  • Nicholas BALL, The Dow Chemical Company
  • George KASS, European Food and Safety Authority (EFSA)
  • Magdalini SACHANA, Organisation for Economic Co-operation and Development (OECD)
  • Stephen FERGUSON, National Institutes of Health/National Institute of Environmental Health Sciences (NIH/NIEHS)
  • John WAMBAUGH, U.S. Environmental Protection Agency (US EPA)
fas|fa-cogs|

Collaborations

Collaborations

RISK-HUNT3R & JRC

RISKHUNT3R actively collaborates with the Joint Research Centre at the level of validation of test methods and the implementation of high-throughput testing, assessment of TTC methods, and definition of strategies toward completely animal-free safety testing. Moreover, JRC will actively participate in the communication to international stakeholders, including regulatory agencies, national reference laboratories, European 3R centres, and industry stakeholders.

RISK-HUNT3R & Tox21 (US EPA, NIH, NIEHS/NTP, FDA)

The Tox21 program is a collaboration among four US government agencies to develop new ways to rapidly test whether substances can have an adverse effect on human health. The approaches taken in Tox21 are complementary to efforts in RISK-HUNT3R in that they also employ NAMs such as high-throughput transcriptomics and other in vitro and in silico-based tests. The application of NAMs in NGRA is a common goal. Several representatives of the Tox21 program are members of the RISK-HUNT3R Scientific and Regulatory Advisory Board (SRAB). To ensure mutually beneficent knowledge exchange between Tox21 and RISK-HUNT3R, regular web-based or physical meetings are organised and working groups are established. These working groups are dedicated to particular topics of interest to both projects and serve to quickly disseminate knowledge and approaches.

Collaboration focus areas:

  • High-throughput methods for NGRA
  • AOP network-based system toxicology
  • High-throughput PBK models
  • Threshold of toxicological concern (TTC) approaches
  • Integration of advanced multi-physiological systems (MPS, including organ-on-a-chip models) for risk assessment

ASPIS

RISK-HUNT3R is one of three projects in the research cluster ASPIS: “Animal-free Safety assessment of chemicals: Project cluster for Implementation of novel Strategies”. Together with the projects ONTOX and PrecisionTOX, these represent Europe’s €60M effort towards the sustainable, animal-free and reliable chemical risk assessment of tomorrow.