The project in short
RISK-HUNT3R, short for “RISK assessment of chemicals integrating HUman centric Next generation Testing strategies promoting the 3Rs”, is a European Research & Innovation project funded under the European Commission’s Horizon 2020 programme. The 5-year project runs from June 2021 with a funded budget of €22.9M. RISK-HUNT3R builds on the outcomes of the Horizon 2020 toxicological flagship project EU-ToxRisk, ending by the end of 2021.
Why?
Science and society are increasingly demanding a paradigm shift towards chemical safety and risk assessment without using animals. In addition to growing ethical concerns around the use of animal studies, there is the fundamental need to address all potential health effects relevant and specific to humans. In addition, due to increasing regulatory demands, the limited laboratory capacity and high costs of animal-based testing is becoming a hurdle for the provision of all desired information requirements for chemicals safety assessment.
How?
The project will develop, validate and implement integrated approaches to lead the way towards next-generation risk assessment (NGRA). Innovative mechanism-based new approach methods (NAMs) will exclusively be in vitro and in silico and relevant for human health. Through systematic and iterative evaluation of its NAM toolbox, the project will optimize a strategy to assess chemical exposure, toxicokinetics, and toxicodynamics.
RISK-HUNT3R will provide a full sustainable framework for NGRA that is human-relevant, fully based on non-animal approaches, and fit for implementation through engagement with chemical safety regulators.
Research cluster ASPIS
RISK-HUNT3R is one of three projects constituting the research cluster ASPIS (“Animal-free Safety assessment of chemicals: Project cluster for Implementation of novel Strategies”). Together with the projects ONTOX and PrecisionTOX, this will represent Europe’s €60M effort towards the sustainable, animal-free and reliable chemical risk assessment of tomorrow.
News
ASPIS Cluster solidarity with Ukraine
We would like to express our solidarity with Ukrainian toxicologists, scientists, students, and the whole Ukrainian nation. We fully condemn the unprovoked military aggression of the Russian government against Ukraine, and we join the numerous calls from around the...
Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation
Abstract Mitochondrial perturbation is a key event in chemical-induced organ toxicities that is incompletely understood. Here, we studied how electron transport chain (ETC) complex I, II, or III (CI, CII and CIII) inhibitors affect mitochondrial functionality, stress...
Newsletter Issue #1 published
The RISK-HUNT3R project has released a new document! Indeed, the first newsletter issue is now available on the public website. You can consult the document by clicking on the following link : Newsletter Issue #1 .
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Interested in #NewApproachMethodology-based testing strategies? Don't miss the #ASCCT webinar featuring presentations from several young scientists including @RISKHUNT3R colleague Kirsten Veltman (@rivm) #ESTIV Best Poster Award Winner at #EUROTOX2023 Congress! 11 Apr, 4 PM CEST
#ASCCT #webinar! On Apr 11 Kirsten Veltman from @RISKHUNT3R consortium partner @rivm will present on her #ESTIV Best Poster Award research topic received at the #EUROTOX2023 Congress. Join us: https://www.ascctox.org/index.php?option=com_jevents&task=icalrepeat.detail&evid=14&Itemid=115&year=2024&month=04&day=11&title=ascct-estiv-award-winners-webinar-3&uid=9444f425c0e80adf1c0e40e6550fe3d2
#NAMs #NextGenerationRiskAssessment #nonanimal #toxicitytesting
Valuable contribution from @RISKHUNT3R consortium partners towards an #animalfree prediction of #human #systemictoxicity! S. Escher, J. Valls & R. Grafström presented their strategies to classify #chemicals based on #NAMs. @EPAA3Rs #Designathon challenge: https://single-market-economy.ec.europa.eu/calls-expression-interest/epaa-launches-designathon-human-systemic-toxicity_en
