The first scientific publication introducing the Alternative Safety Profiling Algorithm (ASPA) has been released in ALTEX (October 2025)!
“An Alternative Safety Profiling Algorithm (ASPA) to Transform Next Generation Risk Assessment into a Structured and Transparent Process” presents a broad-purpose, transparent and reproducible risk assessment workflow, designed to make Next Generation Risk Assessment (NGRA) more structured, traceable and applicable in regulatory contexts.
Developed through collaboration within the ASPIS cluster (RISK-HUNT3R, ONTOX, and PrecisionTox), ASPA integrates data on hazard, ADME, and exposure, and is supported by a user-friendly software, ASPA-assist.
This publication marks an important milestone in advancing animal-free, data-driven approaches to chemical safety assessment, and a big step towards the practical implementation of NGRA.
Leist M, Tangianu S, Affourtit F, Braakhuis H, Colbourne J, Cöllen E, Dreser N, Escher SE, Gardner I, Hahn S, Hardy B, Herzler M, Islam B, Kamp H, Magel V, Marx-Stoelting P, Moné MJ, Lundquist P, Ottenbros I, Ouedraogo G, Pallocca G, van de Water B, Vinken M, White A, Pastor M, Luijten M. An Alternative Safety Profiling Algorithm (ASPA) to transform next generation risk assessment into a structured and transparent process. ALTEX. 2025 Oct 16. doi: 10.14573/altex.2509081. Epub ahead of print. PMID: 41099509. https://www.altex.org/index.php/altex/article/view/3041