May 29, 2024 | Meet RISK-HUNT3R
The RISK-HUNT3R project presented a case study at the EPAA Designathon – New approach methodologies workshop, which was held on the 20th-22nd of March 2024 at the JRC in ISPRA, Italy.
The workshop discussed case studies which proposed a Next Generation Hazard Assessment framework based on NAMs to classify compounds as high, moderate or low toxic with regard to systemic toxicity in humans. Conceptually, toxicodynamic and kinetic properties contribute to this classification. All case studies were asked to assess one to many of 150 preselected model compounds. Beside RHT3R also Ontox and PrecisionTox, also being part of the ASPIS cluster contributed case studies.
RH3R team attending the 2024 EPAA Designathon Workshop.
RHT3R Case Study 2 team presented an integrated approach, which applied high throughput NAM data from ToxCast inventory, the disease associations from the Chemical Effect Predictor as well as high throughput PBK modeling. RHT3R first developed these three models and determined their predictivity with regard to STOT-RE predictions by using about 66 case study compounds from case study 2. Then they performing approach was applied to nine Designathon compounds to predict there STOT-RE classification.
The workshop used the different case studies as starting point to discuss the main principles of NAM based toxicokinetic and dynamic assessment. Discussion of shared assessment elements and main differences helped to crystallize out that it would be a good idea to assess different endpoints by using different criteria and testing approaches, e.g. for acute toxicity, CMR or STOT-RE. While the assumptions and approaches in high throughput kinetic assessments were already fairly similar, more work is needed to agree on the testing strategy for toxicodynamic properties. Workshops like this a needed to evaluate a variety of ideas to then include new ideas into future developments.
RISK-HUNT3R will continue the work in case study 2 using other relevant and promising high throughput methods e.g. expanding to cell painting and reporter based assays. A subset of the Designathon compounds will be used as external validation set.
All information regarding the EPAA Designathon workshop are available here. Recording of the EPAA DESIGNATHON workshop is available here on the European Commission website and a flash report of the event here.
Apr 15, 2024 | Meet RISK-HUNT3R
The RISK-HUNT3R project is pleased to invite all interested stakeholders to the second edition of its public Stakeholder Symposium, taking place on the 11th and 12th of June 2024 at Hotel Zuiderduin in Egmond aan Zee, Netherlands.
The event will be dedicated to RISK-HUNT3R partners and stakeholders from industry, regulatory organizations, and international initiatives on new approach methods (NAM)-based chemical risk assessment.
The second edition of the RISK-HUNT3R Stakeholder Symposium‘s programme will be focusing on four key topics:
- Update on ASPA safety assessment workflow, with examples on practical application and its incorporation into the ASPA dashboard;
- RISK-HUNT3R Case studies on applicability of ASPA for NAM-based NGRA;
- Focus on Case study on hazard endpoints of RISK-HUNT3R;
- Scientific achievements in RISK-HUNT3R at year-3 of project deployment through speed talks and posters.
All precisions on event hours and topics are available to all in the RISK-HUNT3R Stakeholder Symposium agenda.
Register before May 15th by completing the online registration form: here.
For further information, please contact the Project Office at riskhunt3r_arttic@eurtd.com.
Mar 29, 2024 | Meet RISK-HUNT3R
Taking place in Nigara Falls (Canada) on August 27-31 2023, the 12th World Congress on Alternatives and Animal Use in the Life Sciences (WC12) had for objective “to bring together multidisciplinary stakeholders from academia, industry, government, and non-profit sectors under one roof to advance the 3Rs—to reduce, refine, and replace the use of animals in the life sciences”. RISK-HUNT3R partners contributed to the WC12 with several talks and posters.
RISK-HUNT3R/ASPIS information material was distributed at project booth #38 at the conference exhibition.
Unilever organized the well-visited #UseScienceNotAnimals World Café, where several RISK-HUNT3R partners pitched their alternative approaches to animal testing.
Dedicated sessions on ASPIS activities included:
- #S455 Progress in Quantifying Adverse Outcome Pathways to Support Next Generation Risk Assessment chaired by Huan Yang (ONTOX) and Mark Cronin (RISK-HUNT3R);
- #S449 ASPIS: From Molecular Toxicology to Regulatory Acceptance – the Next Steps for Animal-Free Testing chaired by Bob van de Water (RISK-HUNT3R) and Mathieu Vinken (ONTOX).
Matteo Piumatti (Altertox) interviewed several ASPIS members like Dr Gladys Ouédraogo, Sylvia Escher and Elisabet Berggren from RISK-HUNT3R, Eliška Kuchovská and Mathieu Vinken from ONTOX, as well as Jonathan Freedman from PrecisionTox to hear their impressions of the WC12. Videos are available on the Altertox webpage dedicated to the event.
Mar 26, 2024 | Meet RISK-HUNT3R
RISK-HUNT3R members, Tamara Danilyuk and Kirsten Veltman, were awarded for their scientific contributions at EUROTOX2023.
Tamara Danilyuk (Leiden University) received the EUROTOX 2023 Early Career Award/ ECETOC Christa Hennes Award for her work on toxicological research into mechanisms and risk assessment.
Kirsten Veltman (RIVM) with the ESTIV Best Poster Award for her work on the Application of Weighted Gene Co-expression Network Analysis as Mode of Action Screening Method for Suspected Non-Genotoxic Carcinogens Inducing Oxidative Stress.
Jul 26, 2023 | Meet RISK-HUNT3R
Palle Steen Helmke and the RISK-HUNT3R poster on Systemic Fingerprints for Predicting Liver Related Adverse Events at QSAR 2023.
The RISK-HUNT3R project attended the 20th International Workshop on (Q)SAR in Environmental and Health Sciences in June 2023 in Copenhagen, Denmark. Palle Steen Helmke, from University of Vienna (Austria), has received the Best Poster Award 2023 for his work on Systemic Fingerprints for Predicting Liver Related Adverse Events with Barbara Füzi and Gerhard F. Ecker.
The poster awarded is available here.
More information on the QSAR2023 is available here.
Apr 26, 2023 | Meet RISK-HUNT3R, News
The RISK-HUNT3R project is pleased to invite all interested stakeholders to its upcoming Stakeholder Symposium, taking place on the 13th and 14th of June 2023 at Hotel Zuiderduin in Egmond aan Zee, Netherlands.
The event will be dedicated to RISK-HUNT3R partners and stakeholders from industry, regulatory organizations, and international initiatives on new approach methods (NAM)-based chemical risk assessment.
The objectives for the participants of the RISK-HUNT3R Stakeholder Symposium are to:
- Learn about the ASPIS Profiling Algorithm (ASPA), a platform to implement and operationalize NGRA;
- Learn how and where NAMs populate the ASPA modules (hazard, exposure, toxicokinetics & IVIVE, and data integration);
- Engage with the RISK-HUNT3R consortium, learn about further ASPA development, and identify collaborative inroads;
- Get familiar with the NGRA ecosystem and interact with key experts from ongoing chemical risk assessment initiatives.
The agenda is available to all. Online registration is closed.
For further information, please contact the Project Office at riskhunt3r_arttic@eurtd.com.
