The project in short
RISK-HUNT3R, short for “RISK assessment of chemicals integrating HUman centric Next generation Testing strategies promoting the 3Rs”, is a European Research & Innovation project funded under the European Commission’s Horizon 2020 programme. The 5-year project runs from June 2021 with a funded budget of €22.9M. RISK-HUNT3R builds on the outcomes of the Horizon 2020 toxicological flagship project EU-ToxRisk, ending by the end of 2021.
Why?
Science and society are increasingly demanding a paradigm shift towards chemical safety and risk assessment without using animals. In addition to growing ethical concerns around the use of animal studies, there is the fundamental need to address all potential health effects relevant and specific to humans. In addition, due to increasing regulatory demands, the limited laboratory capacity and high costs of animal-based testing is becoming a hurdle for the provision of all desired information requirements for chemicals safety assessment.
How?
The project will develop, validate and implement integrated approaches to lead the way towards next-generation risk assessment (NGRA). Innovative mechanism-based new approach methods (NAMs) will exclusively be in vitro and in silico and relevant for human health. Through systematic and iterative evaluation of its NAM toolbox, the project will optimize a strategy to assess chemical exposure, toxicokinetics, and toxicodynamics.
RISK-HUNT3R will provide a full sustainable framework for NGRA that is human-relevant, fully based on non-animal approaches, and fit for implementation through engagement with chemical safety regulators.
Research cluster ASPIS
RISK-HUNT3R is one of three projects constituting the research cluster ASPIS (“Animal-free Safety assessment of chemicals: Project cluster for Implementation of novel Strategies”). Together with the projects ONTOX and PrecisionTOX, this will represent Europe’s €60M effort towards the sustainable, animal-free and reliable chemical risk assessment of tomorrow.
News
RISK-HUNT3R at EUROTOX 2024: Shaping the Future of Chemical Safety
Taking place in Copenhagen from September 8-11, 2024, the 58th Congress of the European Societies of Toxicology (EUROTOX 2024) brought together experts to explore the theme "Toxicology – A Quest for safe Chemicals and Medicines". Central topics included the safety of...
ASPIS Open Symposium: Advancing Animal-Free Chemical Safety Assessment
The 4th ASPIS Open Symposium took place in Copenhagen from September 11-12, 2024, and gathered experts from the three consortia—PrecisionTox, ONTOX, and RISK-HUNT3R—to showcase the exciting progress made over the past year. New research highlighted advancements in...
RISK-HUNT3R General Assembly and Stakeholder Symposium
The RISK-HUNT3R consortium meeting and second Stakeholder Symposium in Egmond aan Zee, Netherlands on 10-13 June 2024 were filled with valuable discussions and key takeaways that have re-energized us for the next two years of our project work! A big thank you to our...