RISK-HUNT3R hosts ASPIS satellite meeting on Next-Generation Risk Assessment
On 24 October 2024, RISK-HUNT3R, on behalf of the ASPIS cluster, hosted the satellite meeting “ASPA, making next-generation risk assessment happen” as a precursor to the European Commission’s 2nd workshop on “Roadmap Towards Phasing Out Animal Testing for Chemical Safety Assessments.”
The event opened with Bob van de Water (Leiden University) and Mirjam Luijten (RIVM) introducing the ASPA workflow, embodying ASPIS mission and vision for a Next-Generation Risk Assessment (NGRA) framework rooted in new approach methodologies (NAMs). Barira Islam (Certara) followed with a case study demonstrating the integration of in silico and in vitro methods with physiologically based kinetic (PBK) modelling to assess risks from chemicals producing active metabolites. Sylvia Escher (ITEM Fraunhofer) highlighted a prioritization and screening approach to differentiate toxic from low-toxic chemicals, while Ulrika Sahlin (Lund University) addressed uncertainty characterization in NAM-based risk assessments.
The meeting sparked valuable discussions and questions, reinforcing the collective commitment to advancing NAM-based methodologies. A special thank you to our presenters and participants for their contributions to “making NGRA happen.”
For those who could not attend the event in person, our experts have prepared two short videos that provide a comprehensive overview of the background and key findings related to the ASPA presentation. These resources are intended to offer additional insights, allowing for a deeper exploration of the ASPA workflow, and are available on our webpage or YouTube channel.
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Bob van de Water (Leiden University)
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Mirjam Luijten (RIVM)
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Barira Islam (Certara)
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Sylvia Escher (ITEM Fraunhofer)
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Ulrika Sahlin (Lund University)
On 25 October, ASPIS cluster members gathered at a pivotal European Commission workshop dedicated to progressing toward a future of chemical safety assessment without the need for animal testing.
This was the second European Commission (EC) workshop on the Roadmap towards phasing out animal testing in chemical safety assessments, held online and in Brussels. This Roadmap initiative is part of the Commission’s response to the European Citizens’ Initiative (ECI), “Save Cruelty-Free Cosmetics – Commit to a Europe without Animal Testing.” The Commission welcomed ECI and is firmly committed to developing this Roadmap, which will set out specific actions and key milestones toward an animal-free regulatory framework.
The workshop provided an essential platform for dialogue among Member States and stakeholders, underscoring recent advancements. Attendees discussed vital elements, including the development, validation, and implementation of non-animal methods, and explored ways to integrate these methods across existing chemical legislation.
Representatives from ASPIS’s three projects – RISK-HUNT3R, ONTOX, and PrecisionTox – shared updates on their innovative contributions, highlighting how these efforts support the Commission’s Roadmap.
Critical contributors to these discussions included Mathieu Vinken (ONTOX coordinator, Vrije Universiteit Brussel), Martijn Moné (RISK-HUNT3R, Leiden University), Sylvia Escher (RISK-HUNT3R, ITEM Fraunhofer) and Leonie Mueller (PrecisionTox, Altertox Academy).
As explained Mathieu Vinken, ONTOX coordinator and ASPIS cluster chair for 2024-2026:
“The meeting showed again the importance of 3I (interdisciplinary, intersectoral and international) collaboration for full implementation of the 3Rs. ASPIS, and therefore ONTOX, sets an excellent example in this respect. By joining forces between the 3 consortia, a major contribution to the replacement of animal testing in the safety evaluation of chemicals is provided.”
In closing, the workshop reinforced the collaborative momentum driving NGRA and NAM-based risk assessments forward, paving the way for further progress towards animal-free safety evaluations.
The European Commission aims to release the final Roadmap by the first quarter of 2026, outlining key milestones and essential steps for transitioning to animal-free chemical legislation.